Cell Signaling Technology

Press Releases

Cell Signaling Technology Expands Partnership with Bio-Rad to Develop Phosphoprotein Assays for Kinase and Signal Transduction Research and Drug Discovery

DANVERS, MA – June 6, 2006 – Cell Signaling Technology, Inc. (CST), announced today that it has entered into a new partnership agreement with Bio-Rad Laboratories, Inc. (AMEX: BIO and BIOb), a multinational manufacturer and distributor of life science research products and clinical diagnostics. Under the new agreement, CST will develop antibodies for kinase activation and protein phosphorylation assays that will be commercialized in Bio-Rad’s multiplex bead-based assays for the Bio-Plex® suspension array system.

CST’s scientific and technical expertise will be leveraged to develop a broader array of antibodies for Bio-Rad’s Bio-Plex® platform, enabling multiplexed measurement of phosphoproteins and signaling pathways. Bio-Plex® phosphoprotein assays are optimized for simultaneous assessment of kinase and signaling protein activation states and provide critical tools for disease research and drug development. Given the complexity of cellular signaling and the diversity of mechanistic abnormalities underlying disease, Bio-Plex® multiplexed phosphoprotein assays can facilitate the understanding of disease and the development of more effective targeted therapeutic strategies.

“Our partnership with Bio-Rad in the past has enabled CST to combine our antibody expertise with Bio-Rad’s strength in multiplexed assay technologies,” said Christopher Bunker, CST’s Director of Pharma Services. “Bio-Plex phosphoprotein assays built with CST antibody content provide the means for rigorous parallel analysis of signal transduction pathways.”

“Advances in cellular signaling research will have a great impact both in our understanding of fundamental biological processes and in advancing the treatment of disease,” said Bio-Rad Vice President and Group Manager, Life Science Group, Brad Crutchfield. “Together, CST and Bio-Rad can provide more quickly a broader array of tools for kinase and signal transduction research.”

About Cell Signaling Technology

Cell Signaling Technology, Inc., has expertise and the market leadership position in the development and commercialization of phospho-specific antibodies and assays for kinase and pathway analysis. CST’s phospho-specific antibodies are validated in multiple assay platforms and are critical reagents in basic scientific and drug discovery research. Information on CST can be obtained at the Company’s website at www.cellsignal.com

About Bio-Rad

Bio-Rad Laboratories, Inc. (www.bio-rad.com), is a multinational manufacturer and distributor of life science research products and clinical diagnostics. Based in Hercules, California, Bio-Rad serves more than 70,000 research and industry customers worldwide through a network of more than 30 wholly owned subsidiary offices.

Various statements made within this press release may constitute “forward-looking statements” for purposes of the Securities and Exchange Commission’s “safe harbor” provisions under the Private Securities Litigation Reform Act of 1995 and Rule 3b-6 under the Securities Exchange Act of 1934. The forward-looking statements contained herein involve risks and uncertainties that could cause results to differ materially from the Company’s expectations.

For more information, contact:

Eric Scharf
Cell Signaling Technology, Inc.
Director of Marketing
phone: (978) 867-2349
e-mail: escharf@cellsignal.com

Tina Cuccia
Bio-Rad Laboratories, Inc.
Corporate Communications Manager
Phone (510) 741-6063
e-mail: tina_cuccia@bio-rad.com

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