Cell Signaling Technology Announces Alliance with Merck to Provide PhosphoScan® Proteomics & Antibody Development for Biomarker Discovery to Support Oncology Therapeutic Programs
Danvers, MA, March 27, 2007 – Cell Signaling Technology, Inc. (CST) announced today an alliance with Merck under which it will provide its patented PhosphoScan® proteomics technology for biomarker discovery and its expertise in antibody development and validation to develop high specificity biomarker assays to help advance Merck’s targeted therapeutic programs for oncology.
CST’s PhosphoScan® technology enables the discovery of drug target phospho-profiles (Phospho-Signatures®) in cells and disease tissues. PhosphoScan®, which involves immunoaffinity purification and mass spectroscopy, was described in the journal Nature Biotechnology (Rush J. et al, Nat. Biotechnol. 23, 94-101 (2005)). Discoveries made with PhosphoScan® may provide the basis for biomarker assay development by CST, employing its expertise in antibody and immuno-assay validation. Assays developed under the alliance may be useful within Merck’s drug development programs.
“Our alliance with Merck represents an excellent opportunity for CST to employ its biomarker discovery and development capabilities, integrating PhosphoScan® proteomics with our expertise in antibody development and validation,” said Christopher Bunker, CST’s Director of Pharma Services. “We are excited about focusing our PhosphoScan® platform on Merck’s targeted inhibitors to identify drug-response Phospho-Signatures® that will guide the development of antibodies for use in cancer profiling studies and biomarker validation.”
About Cell Signaling Technology, Inc.
Cell Signaling Technology, Inc. has expertise and the market leadership position in the development and commercialization of phospho-specific antibodies and assays for kinase and pathway analysis. CST’s phospho-specific antibodies are validated in multiple assay platforms and are critical reagents in all stages of pharmaceutical drug discovery and development. CST has developed and optimized procedures enabling the delivery of high value reagents, immuno-assays and contract services for research and drug development markets focused on cellular phosphorylation and signaling analysis profiles. Information on CST can be obtained at the Company’s website at www.cellsignal.com.