Peter Hornbeck, Director, PhosphoSitePlus®
Peter Hornbeck
- Director, PhosphoSitePlus®
- Ph.D., University of California, San Francisco
Dr. Hornbeck and his team of bioinformaticists focus on aggregating and analyzing information about the post-translational modifications (PTMs) of proteins, providing a comprehensive framework that informs both basic research and business decisions at Cell Signaling Technology (CST). Their core work includes the ongoing manual curation of published articles and datasets from original mass spectrometry work performed at CST. Their research includes applying natural language processing as an adjunct to manual curation of the literature, developing and disseminating tools for pathway analyses, and developing methods for visualizing and analyzing structural patterns and the molecular topology of PTMs. They have been responsible for the development of PhosphoSitePlus® (PSP), a comprehensive, and interactive web-based resource for studying the experimentally observed PTMs of mammalian proteins. Multiple rounds of funding from the NIH, as well as ongoing support from CST, have enabled PSP to become the premiere resource for studying the role of protein modifications in cellular signaling, with special emphasis upon those observed in various cancers. PSP is freely available to the research community, reflecting the core commitment of CST to advancing the role of cellular signaling in health and disease, and allowing us to return value to the research community for their continued support over the years.
Dr. Hornbeck has wide ranging research experience in molecular evolution, biochemistry, immune regulation, protein phosphorylation, and bioinformatics. He received his B.A. in Anthropology from Cal Berkeley and his Ph.D. in Microbiology and Immunology from the University of California, San Francisco; completed postdoctoral training in the Laboratory of Immunology at the National Institutes of Health; and was on the faculty of Medicine and Microbiology at the University of Maryland School of Medicine. He started PhosphoProtein Databases, Inc., a consulting firm, in 1996, and joined CST in 1998. The Cancer Research Institute, the American Cancer Society, and the National Institutes of Health have supported his research.
Selected Publications
- Hornbeck PV, Kornhauser JM, Tkachev S, Zhang B, Skrzypek E, Murray B, Latham V, Sullivan M (2012) PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse. Nucleic Acids Res. 40(1), D261–70.
- Sriram G, Reichman C, Tunceroglu A, Kaushal N, Saleh T, Machida K, Mayer B, Ge Q, Li J, Hornbeck P, Kalodimos CG, Birge RB (2011) Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivation. Oncogene 30(46), 4645–55.
- ten Klooster JP, Jansen M, Yuan J, Oorschot V, Begthel H, Di Giacomo V, Colland F, de Koning J, Maurice MM, Hornbeck P, Clevers H (2009) Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. Dev. Cell 16(4), 551–62.
- Zhang H, Zha X, Tan Y, Hornbeck PV, Mastrangelo AJ, Alessi DR, Polakiewicz RD, Comb MJ (2002) Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs. J. Biol. Chem. 277(42), 39379-87.
- Hornbeck P, Huang KP, Paul WE (1988) Lamin B is rapidly phosphorylated in lymphocytes after activation of protein kinase C. Proc. Natl. Acad. Sci. U.S.A. 85(7), 2279–83.
- Hornbeck P, Paul WE (1986) Anti-immunoglobulin and phorbol ester induce phosphorylation of proteins associated with the plasma membrane and cytoskeleton in murine B lymphocytes. J. Biol. Chem. 261(31), 14817–24.
- Hornbeck PV, Lewis GK (1985) Idiotype connectance in the immune system. II. A heavy chain variable region idiotope that dominates the antibody response to the p-azobenzenearsonate group is a minor idiotope in the response to trinitrophenyl group. J. Exp. Med. 161(1), 53–71.
- Hornbeck PV, Wilson AC (1984) Local effects of amino acid substitutions on the active site region of lysozyme: a comparison of physical and immunological results. Biochemistry 23(5), 998–1002.
- Hornbeck PV, Swindler DR (1967) Morphology of the lower fourth premolar of certain cercopithecidae. J. Dent. Res. 46(5), 979–83.
