Signaling Pathways in Cancer
Cell growth and survival are regulated by complex signaling pathways that can be disrupted to cause cancer. These pathways comprise receptor tyrosine kinases (RTKs) such as EGFR, HER2, ALK, and ROS1 and their corresponding downstream signaling targets, including PI3K/Akt, MAPK, and others, to regulate cell proliferation, migration, apoptosis, and differentiation. Genetic mutations in RTKs or their downstream nodes can result in aberrant signaling and lead to uncontrolled cell growth.
Scienstists at CST collaborate with key opinion leaders in cancer research to create reference pathway diagrams that reflect the latest thinking in the research community. Over 40 pathway diagrams currently exist, including the Warburg Effect, ErbB/HER Signaling, PI3K/Akt Signaling and others. View a complete list of our reference pathways.