Cancer is the leading cause of death worldwide and has touched us all in one way or another. At Cell Signaling Technology, we are committed to making a difference in the research efforts directed against this devastating disease. Our Cancer Research Group is dedicated to unraveling the signaling networks that underlie this disease and has published their findings in high impact, peer-reviewed journals. To better understand these signaling networks, our PTMScan® Technology Group has developed innovative proteomic technologies for the study and analysis of the cancer proteome. To support the global scientific research community, our in-house scientists collaborate with experts in the field to produce insightful reference material such as our pathway diagrams as well as hosting educational symposiums to communicate and share the most up-to-date knowledge in cancer signaling. And, of course, our development scientists use all this research knowledge to produce the highest quality antibodies against thoughtful, cutting-edge targets that have been validated in the most meaningful research applications. We want to make a difference, and we want to give you the tools to make a difference too.
Cell Signaling Technology offers sensitive and specific antibodies to the most important targets in cancer signaling and protocols to support your research.
This short 3D rendered animation illustrates Caspase-mediated apoptosome formation and activation, from release of cytochrome C by mitochondria to prototeolytic degradation of cellular components such as actin filaments.
Cell Signaling Technology is now offering two highly sensitive research antibodies for detection of ALK and ROS1 full-length proteins and C-terminal fusion proteins.
Our Proteomics Group developed PTMScan Technology, an innovative proteomics technology that combines immunoaffinity purification and mass spectrometry to identify and quantify post-translational modifications on a global scale, including phosphorylation, ubiquitination, methylation, and acetylation. This technology has been used by research laboratories all over the world to study the signaling pathways that underlie disease.
Browse the list of high impact journals such as Cell, Science Signaling, and Clinical Cancer Research that feature our Cell Signaling Technology research scientists.
- Hanahan, D and Weinberg, RA. (2000) Cell, 100, 57-70.
- Hanahan, D and Weinberg, RA. (2011) Cell, 144, 646-674.