SAM Protein Domain
The SAM domain from the EphA4 receptor.
Domain Binding and Function
The approximately 70 amino acid SAM (Sterile α Motif) domain has been identified from over 400 different proteins responsible for diverse cellular functions in organisms from yeast to man. SAM domains are implicated in mediating protein-protein interactions by forming homo- and heterotypic oligomers. The residues at the interface of the EphA4 and EphB2 SAM domain homodimers have been mapped, but the factors that determine specificity remain unclear.
- Stapleton, D. et al. (1999) Nat. Struct. Biol. 6(1), 44–49.
Examples of Domain Proteins
|SAM Domain Proteins||Binding Partners|
|Polycomb group chromatin remodeling proteins:|
|Scm||Homotypic and heterotypic interactions|
|Ph||Homotypic and heterotypic interactions|
|Rae 28||Homotypic and heterotypic interactions|
|Ste11 Yeast MAPKKK||Ste50|
|Tel ETS Family Transcription Factor||Tel|