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Pathway Description:

The synthesis of new protein is a highly regulated process that allows rapid cellular responses to diverse stimuli post-transcriptionally. Eukaryotic translation initiation factors (eIFs) catalyze the assembly of a functional ribosomal complex, which includes the 40S subunit, mRNA, and the initiator Met-tRNA, and finally the 60S subunit before the first peptide bond is formed. Most regulatory stimuli, such as growth factors and stress, control rate-limiting steps of the initiation process by either stimulating or inhibiting specific eIFs. Elevated levels of Ca2+ or cAMP can also attenuate translation by blocking the action of eukaryotic elongation factor 2 (eEF2).

Selected Reviews:

We would like to thank Carson Thoreen and David Sabatini, Whitehead Institute for Biomedical Research, MIT, Cambridge, MA, for reviewing this diagram.

created January 2002

revised November 2012