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Technical Support

Our scientists are at the bench daily to produce and validate our antibodies, so they have hands-on experience and knowledge of each antibody’s performance.

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PTMScan® Direct utilizes LC/MS techniques and can be followed up with traditional antibody screening methods. The highest quality antibody products employed in PTMScan® Direct are readily available from Cell Signaling Technology for many of the endpoint markers.

Features & Benefits

  • Identification and quantification of up to hundreds of signaling nodes from multiple signaling pathways, enabling the most comprehensive pathway analysis profiling available.
  • Direct measurement of specific peptide targets using LC/MS alleviates background levels that are intrinsic to other protein-based assays, and allows for greater assay sensitivity and enhanced dynamic range.
  • The start-to-finish service, performed by scientists at Cell Signaling Technology with over 30 years of combined LC/MS expertise, provides you with timely and high-quality results.
  • Deliverables include comprehensive result tables and a PowerPoint report containing a study overview and a result table guide, facilitating independent analysis and dissemination of your results.
  • Premium PTMScan Direct Service deliverables will include an easy-to-read final report summarizing all findings.
PTMScan Direct Ribbon
 

PTMScan® Direct Multi-Pathway

PTMScan® Direct Multi-Pathway Service allows access to perform targeted screening and quantification of a defined set of protein sites and signaling nodes critical for drug discovery, biomarker discovery, or diagnostic development. The PTMScan Direct Multi-Pathway Service spans a large number of pathways, including Akt, MAPK, NF-κB, and Jak/Stat signaling pathways. The table below illustrates the list of protein sites that can be monitored with PTMScan® Direct Multi-Pathway Service.

Altogether, the PTMScan® Direct Multi-Pathway service provides a robust method to qualitatively identify and quantitatively profile 1006 unique phosphorylations sites to 409 proteins.

Highlighted purple nodes designate targeted protein modification sites within each sample signaling pathways that can be monitored with PTMScan® Direct Multi-Pathway Service.

Monitored phosphorylation in Adherens Junction Dynamics

Adherens Junction Dynamics

Monitored phosphorylation in AMPK Signaling

AMPK Signaling

Monitored phosphorylation in B Cell Receptor Signaling

B Cell Receptor Signaling

Monitored phosphorylation in Cell Cycle Control: G1/S Checkpoint

Cell Cycle Control: G1/S Checkpoint

Monitored phosphorylation in Cell Cycle Control: G2/M DNA Damage Checkpoint

Cell Cycle Control: G2/M DNA Damage Checkpoint

Monitored phosphorylation in ErbB / HER Signaling

ErbB / HER Signaling

Monitored phosphorylation in G Protein-coupled Receptors Signaling to MAPK / Erk

G Protein-coupled Receptors Signaling to MAPK / Erk

Monitored phosphorylation in Insulin Receptor Signaling

Insulin Receptor Signaling

Monitored phosphorylation in Jak / Stat Signaling: IL-6 Receptor Family

Jak / Stat Signaling: IL-6 Receptor Family

Monitored phosphorylation in Mitogen Activated Protein Kinase Signaling Cascades

Mitogen Activated Protein Kinase Signaling Cascades

Monitored phosphorylation in MAPK / Erk in Growth and Differentiation

MAPK / Erk in Growth and Differentiation

Monitored phosphorylation in NF-κB Signaling

NF-κB Signaling

Monitored phosphorylation in PI3 Kinase / Akt Signaling

PI3 Kinase / Akt Signaling

Monitored phosphorylation in Regulation of Actin Dynamics

Regulation of Actin Dynamics

Monitored phosphorylation in Regulation of Microtubule Dynamics

Regulation of Microtubule Dynamics

Monitored phosphorylation in SAPK / JNK Signaling Cascades

SAPK / JNK Signaling Cascades

Monitored phosphorylation in Signaling Pathways Activating p38 MAPK

Signaling Pathways Activating p38 MAPK

Monitored phosphorylation in T Cell Receptor Signaling

T Cell Receptor Signaling

Monitored phosphorylation in Toll-like Receptor Signaling

Toll-like Receptor Signaling

PTMScan Multi-Pathway Sample Report

PTMScan Multi-Pathway Sample Report

PTMScan Multi-Pathway Sample Report  4.7 MB

PTMScan® Direct Multi-Pathway Protein Sites
PTMScan® Direct Multi-Pathway Protein Sites  
4E-BP1 (Ser35) 4E-BP1 (Ser44) 4E-BP1 (Thr36) 4E-BP1 (Thr37)
4E-BP1 (Thr41) 4E-BP1 (Thr45) 4E-BP1 (Thr46) 4E-BP1 (Thr50)
4E-BP1 (Tyr34) 4E-BP1 (Tyr54) 4E-BP2 (Ser44) 4E-BP2 (Thr36)
4E-BP2 (Thr37) 4E-BP2 (Thr41) 4E-BP2 (Thr45) 4E-BP2 (Thr46)
4E-BP2 (Thr50) 4E-BP2 (Tyr34) 4E-BP2 (Tyr54) 4E-BP3 (Thr23)
4E-BP3 (Thr32) 53BP2 (Tyr610) A-Raf (Ser157) A-Raf (Ser299)
A-Raf (Tyr155) A-Raf (Tyr296) A-Raf (Tyr302) a-Tublin
Abi-2 (Ser216) Abi-2 (Tyr213) Abi-2 iso2 (Ser210) Abi-2 iso2 (Tyr207)
Abl (Ser113) Abl (Tyr115) Abl iso2 (Ser132) Abl iso2 (Tyr134)
Ack (Ser867) Ack (Tyr859) Ack (Tyr860) Ack iso3 (Ser945)
Ack iso3 (Tyr937) Ack iso3 (Tyr938) AFAP1L2 (Tyr54) AFAP1L2 (Tyr56)
AKNA (Ser997) Akt1 (Ser473) Akt1 (Thr305) Akt1 (Thr308)
Akt1 (Thr312) Akt1 (Thr479) Akt1 (Tyr474) Akt2
Akt2 (Ser474) Akt2 (Ser476) Akt2 (Ser478) Akt2 (Thr306)
Akt2 (Thr309) Akt2 (Thr313) Akt2 (Tyr122) Akt2 (Tyr316)
Akt2 (Tyr475) Akt3 (Ser472) Akt3 (Ser474) Akt3 (Ser476)
Akt3 (Thr302) Akt3 (Thr305) Akt3 (Tyr473) ANP-β (Thr540)
ANP-β iso2 (Thr540) Arg (Ser159) Arg (Tyr161) Arg iso4 (Ser123)
Arg iso4 (Tyr125) Arg iso6 (Ser138) Arg iso6 (Tyr140) ARHGEF17 (Ser383)
ATF-2 (Thr69) ATF-2 (Thr71) ATF-7 ATF-7 (Ser424)
ATF-7 (Ser428) ATF-7 (Ser429) ATF-7 (Ser434) ATF-7 (Thr418)
ATF-7 (Thr432) ATF-7 (Tyr421) ATF-7 iso2 (Ser392) ATF-7 iso2 (Ser396)
ATF-7 iso2 (Ser397) ATF-7 iso2 (Ser402) ATF-7 iso2 (Thr386) ATF-7 iso2 (Thr400)
ATF-7 iso2 (Tyr389) ATG2A (Tyr1314) ATM (Ser1981) ATM (Ser1988)
Aurora A (Thr287) Aurora A (Thr288) Aurora A (Thr292) Aurora B (Thr232)
Aurora B (Thr236) Aurora C (Thr198) Aurora C (Thr202) Aurora C iso2 (Thr164)
Aurora C iso2 (Thr168) Axl (Tyr702) Axl (Tyr703) b-Actin
B-Raf (Ser446) B-Raf (Ser447) B-Raf (Thr440) Bad (Ser71)
Bad (Ser74) Bad (Ser75) Bad (Ser91) Bad (Thr80)
Bad (Tyr76) BAG3 BAG3 (Tyr86) BAG3 (Tyr93)
Bcr/Abl (Ser773) Bcr/Abl (Tyr775) Bcr/Abl iso2 (Ser627) Bcr/Abl iso2 (Tyr629)
BLM (Ser74) BMPR2 (Ser547) BMPR2 (Ser548) BMPR2 (Ser549)
BMPR2 (Tyr546) BMPR2 (Tyr551) Caspase-3 (Asp175) Caspase-3 (Ser176)
Caveolin-1 (Thr15) Caveolin-1 (Tyr14) Caveolin-1 (Tyr25) Caveolin-1 (Tyr6)
CBP (Ser1578) CCNB1 CD28 (Tyr191) CD2AP (Ser542)
CD2AP (Ser546) CD2AP (Ser550) CD2AP (Ser553) CD2AP (Ser554)
CD2AP (Thr539) CD2AP (Thr551) CD2AP (Tyr541) CD2AP (Tyr548)
CD45 (Tyr705) Cdc25C (Ser168) Cdc25C iso3 (Ser125) CDK1
CDK1 (Thr14) CDK1 (Tyr15) CDK1 (Tyr19) CDK2
CDK2 (Thr14) CDK2 (Tyr15) CDK3 CDK3 (Thr14)
CDK3 (Tyr15) CDK5 (Tyr15) CdkL5 (Ser446) CdkL5 (Ser465)
CdkL5 (Ser468) CdkL5 (Tyr171) CdkL5 (Tyr614) CELSR2 (Tyr2679)
CENTD2 (Tyr431) CENTD2 iso1 (Tyr191) CHERP (Ser902) CHERP (Ser904)
Chk1 (Ser343) Chk1 (Ser345) Chk1 (Ser357) Chk1 (Thr362)
CK1-G2 (Ser32) CK1-G3 (Ser31) CK1-G3 iso3 (Ser31) Claudin-4 (Tyr208)
Cortactin (Tyr334) Cortactin iso3 (Tyr297) CRIP2 (Ser74) CRIP2 (Tyr75)
CRIP2 (Tyr77) CTNNA1 CTNNA2 CTNNB1
CTNNB1 (Ser552) CTNNB1 (Ser675) CTNNB1 (Ser680) CTNNB1 (Ser681)
CTNNB1 (Thr551) CTNNB1 (Thr556) CTNNB1 (Thr679) CTTN
DBNDD1 (Ser119) DBNDD1 (Ser121) DBNDD1 (Thr123) DBNL (Tyr162)
DBNL iso2 (Tyr162) DBNL iso3 (Tyr162) DDR1 (Tyr792) DDR1 (Tyr796)
DDR1 (Tyr797) DDX29 (Tyr808) DDX29 (Tyr811) Deptor (Ser279)
Deptor (Ser280) Deptor (Ser282) Deptor (Ser283) Deptor (Ser291)
Deptor (Ser292) Deptor (Ser293) Deptor (Ser299) Deptor (Thr295)
Desmoglein 2 (Ser1059) Desmoglein 2 (Ser1060) Desmoglein 2 (Ser1068) Desmoglein 2 (Thr1056)
Desmoglein 2 (Tyr1061) Desmoglein 2 (Tyr940) Desmoplakin 3 (Ser36) Desmoplakin 3 (Ser39)
Desmoplakin 3 (Ser665) Desmoplakin 3 (Thr21) Desmoplakin 3 (Tyr20) Desmoplakin 3 (Tyr22)
Diaphanous 1 (Tyr128) Diaphanous 1 iso2 (Tyr119) DNA-PK (Ser893) DOT1L (Ser741)
DOT1L (Ser753) DOT1L (Thr735) DOT1L (Thr751) DOT1L (Tyr738)
DYNLL1 DYNLL2 DYRK1A (Tyr321) DYRK1A iso2 (Tyr312)
DYRK1A iso4 (Tyr321) DYRK1B (Tyr273) DYRK1B iso2 (Tyr273) eEF1A1 (Tyr177)
eEF1AL3 (Tyr177) EGFR (Tyr869) EIF1AX eIF1AX (Ser74)
eIF1AX (Thr73) EIF1AY eIF1AY (Ser74) eIF1AY (Thr73)
EIF2A EIF2S1 EIF4EBP2 EIF4H
EphB4 (Tyr574) EphB4 (Tyr581) ERC1 (Ser897) ERC1 iso4 (Ser829)
Erk1 Erk1 (Thr202) Erk1 (Tyr204) Erk2
Erk2 (Thr185) Erk2 (Tyr187) Erk3 Erk5 (Thr219)
Erk5 (Tyr221) FAK (Ser574) FAK (Thr575) FAK (Tyr194)
FAK (Tyr570) FAK (Tyr576) FAK (Tyr577) FAK iso2 (Ser422)
FAK iso2 (Thr423) FAK iso2 (Tyr13) FAK iso2 (Tyr418) FAK iso2 (Tyr424)
FAK iso2 (Tyr425) FAK iso5 (Ser574) FAK iso5 (Thr575) FAK iso5 (Tyr194)
FAK iso5 (Tyr570) FAK iso5 (Tyr576) FAK iso5 (Tyr577) FGFR1 (Tyr583)
FGFR1 (Tyr585) FGFR1 (Tyr653) FGFR1 (Tyr654) FGFR4 (Tyr642)
FGFR4 (Tyr643) FGFR4 iso3 (Tyr874) FGFR4 iso3 (Tyr875) FLVCR1 (Tyr22)
FOXK1 (Thr273) Fyn (Tyr420) Fyn iso2 (Tyr417) G-α-s (Tyr190)
G-α-s iso2 (Tyr176) G-α-s iso3 (Tyr175) G-α-s iso4 (Tyr833) G-α-s iso5 (Tyr819)
Gab2 (Ser474) Gab2 (Ser480) Gab2 (Ser488) Gab2 (Tyr476)
GADS (Tyr45) GAPDH GIT1 (Ser508) GIT1 (Tyr510)
GIT1 iso3 (Ser521) GIT1 iso3 (Tyr523) GRB2 GSK-3α (Ser20)
GSK-3α (Ser21) GSK-3α (Ser278) GSK-3α (Ser39) GSK-3α (Ser41)
GSK-3α (Thr19) GSK-3α (Tyr279) GSK-3β (Ser215) GSK-3β (Tyr216)
GSK-3β iso2 (Ser215) GSK-3β iso2 (Tyr216) H3 Hck (Ser520)
Hck (Tyr411) Hck (Tyr51) Hck (Tyr522) HER3 (Tyr1054)
HIPK1 (Ser355) HIPK1 (Tyr352) HIPK2 (Ser364) HIPK2 (Tyr361)
HIPK3 (Tyr359) hnRNP C1/C2 (Ser121) hnRNP C1/C2 iso2 (Ser100) hnRNP C1/C2 iso2 (Ser107)
hnRNP C1/C2 iso2 (Ser108) hnRNP C1/C2 iso2 (Tyr105) hnRNP C1/C2 iso4 (Ser100) hnRNP C1/C2 iso4 (Ser107)
hnRNP C1/C2 iso4 (Ser108) hnRNP C1/C2 iso4 (Tyr105) HNRPLL (Ser61) Hrs (Ser240)
Hrs (Thr239) Hrs (Thr287) Hrs (Tyr286) HSP90AA1
HSP90AB1 HSPB1 HUS1B (Ser121) ICK (Thr162)
ICK (Tyr159) IGF1R (Tyr1161) IGF1R (Tyr1165) IGF1R (Tyr1166)
IkBα (Ser36) IkBε (Ser157) IkBε iso3 (Ser80) IKKγ (Ser376)
IKKγ (Ser377) IKKγ (Ser383) IKKγ (Tyr374) InsR (Tyr1185)
InsR (Tyr1189) InsR (Tyr1190) InsR iso2 (Tyr1173) InsR iso2 (Tyr1177)
InsR iso2 (Tyr1178) IRS1 IRS-1 (Ser463) IRS-1 (Tyr465)
IRS-2 (Thr544) IRS-2 (Tyr540) IRS-2 (Tyr542) ITK (Tyr220)
JNK1 (Thr183) JNK1 (Tyr185) JNK1 iso2 (Thr183) JNK1 iso2 (Tyr185)
JNK2 (Thr183) JNK2 (Thr188) JNK2 (Tyr185) JNK2 iso2 (Thr183)
JNK2 iso2 (Thr188) JNK2 iso2 (Tyr185) JNK2 iso3 (Thr183) JNK2 iso3 (Thr188)
JNK2 iso3 (Tyr185) JNK3 (Thr221) JNK3 (Tyr223) JNK3 iso2 (Thr221)
JNK3 iso2 (Tyr223) Jun (Ser73) JunD (Ser100) JunD (Ser90)
KIRREL (Tyr622) KIRREL (Tyr625) KTN1 (Ser242) KTN1 (Ser243)
KTN1 (Thr231) KTN1 (Thr232) KTN1 (Tyr233) Lamin A/C (Ser404)
Lamin A/C (Ser407) Lamin A/C iso2 (Ser404) Lamin A/C iso2 (Ser407) LARP (Ser293)
LARP (Ser627) LARP (Ser631) LARP (Thr303) LARP (Tyr296)
LARP (Tyr633) LARP iso3 (Ser216) LARP iso3 (Ser550) LARP iso3 (Ser554)
LARP iso3 (Thr226) LARP iso3 (Tyr219) LARP iso3 (Tyr556) LARP iso4 (Ser293)
LARP iso4 (Ser627) LARP iso4 (Ser631) LARP iso4 (Thr303) LARP iso4 (Tyr296)
LARP iso4 (Tyr633) Latrophilin 2 (Tyr1372) Latrophilin 2 (Tyr1406) Latrophilin 2 (Tyr1407)
Latrophilin 2 iso2 (Tyr1316) Latrophilin 2 iso2 (Tyr1350) Latrophilin 2 iso2 (Tyr1351) LBR (Ser159)
LBR (Ser167) LBR (Tyr161) LBR (Tyr166) LBR (Tyr22)
Lck (Tyr394) LEMD2 (Ser499) LEMD2 (Ser501) LISCH (Ser321)
LISCH (Ser326) LISCH (Ser332) LISCH (Thr327) LISCH (Tyr323)
LISCH (Tyr328) LISCH (Tyr372) LMO7 (Ser318) LMO7 (Ser322)
LMO7 (Tyr323) LMO7 iso2 (Ser318) LMO7 iso2 (Ser322) LMO7 iso2 (Tyr323)
LMO7 iso3 (Ser318) LMO7 iso3 (Ser322) LMO7 iso3 (Tyr323) LPP (Tyr273)
LPP (Tyr275) LRP6 (Ser1490) LRP6 (Thr1479) LRP6 (Thr1493)
LRP6 (Tyr1480) LRRK1 (Ser360) LRRK1 (Thr358) Lyn (Tyr397)
Lyn iso2 (Tyr376) Lyric (Tyr364) Lyric iso3 (Tyr364) MAP1B (Ser1171)
MAP1B (Ser1322) MAP1B (Ser1324) MAP1B (Ser1326) MAP1B (Ser1330)
MAP1B (Ser1339) MAP1B (Ser1396) MAP1B (Ser1400) MAP1B (Ser1406)
MAP1B (Ser1412) MAP1B (Ser1443) MAP1B (Ser1869) MAP1B (Ser1899)
MAP1B (Ser1915) MAP1B (Ser1917) MAP1B (Ser1922) MAP1B (Ser1939)
MAP1B (Ser1956) MAP1B (Ser1973) MAP1B (Ser2007) MAP1B (Ser2024)
MAP1B (Thr1334) MAP1B (Thr1864) MAP1B (Thr1898) MAP1B (Thr1925)
MAP1B (Thr1964) MAP1B (Thr2010) MAP1B (Thr2011) MAP1B (Thr2034)
MAP1B (Tyr1170) MAP1B (Tyr1174) MAP1B (Tyr1336) MAP1B (Tyr1337)
MAP1B (Tyr1410) MAP1B (Tyr1454) MAP1B (Tyr1870) MAP1B (Tyr1872)
MAP1B (Tyr1904) MAP1B (Tyr1905) MAP1B (Tyr1906) MAP1B (Tyr1921)
MAP1B (Tyr1923) MAP1B (Tyr1938) MAP1B (Tyr1940) MAP1B (Tyr1955)
MAP1B (Tyr1972) MAP1B (Tyr1974) MAP1B (Tyr2006) MAP1B (Tyr2023)
MAP1B (Tyr2040) MAP1B (Tyr2042) MAP1B (Tyr2057) MAP1B (Tyr2059)
MAP4 (Tyr47) MAP4 iso5 (Tyr47) MAP4 iso9 (Tyr47) MCM2 (Ser139)
MCM2 (Tyr137) MEK1 (Ser218) MEK1 (Ser222) MEK2 (Ser222)
MEK2 (Ser226) MEKK2 (Ser164) MEKK2 (Tyr169) Mer (Tyr749)
Mer (Tyr753) Mer (Tyr754) Met (Ser1236) Met (Tyr1234)
Met (Tyr1235) MINK (Tyr505) MINK (Tyr507) MINK iso4 (Tyr505)
MINK iso4 (Tyr507) MKK3 (Ser253) MKP-1 (Ser359) MKP-1 (Ser364)
MKP-1 (Ser366) MLF1 (Ser34) MLK4 (Tyr1028) MRCKa (Ser1545)
MRCKa (Tyr1544) MRCKa iso2 (Ser1567) MRCKa iso2 (Tyr1566) MRCKa iso3 (Ser1451)
MRCKa iso3 (Tyr1450) MSK1 (Ser376) MSK1 (Ser381) MSK1 (Tyr375)
MSK2 (Ser360) MSK2 (Ser365) MSK2 (Tyr359) MSK2 iso2 (Ser360)
MSK2 iso2 (Ser365) MSK2 iso2 (Tyr359) MST3 (Thr182) MST3 (Thr184)
MST3 (Thr190) MST3 (Thr194) MST3 iso2 (Thr170) MST3 iso2 (Thr172)
MST3 iso2 (Thr178) MST3 iso2 (Thr182) MTHFD1 mTOR (Ser2442)
mTOR (Ser2448) mTOR (Ser2450) mTOR (Ser2454) mTOR (Thr2444)
mTOR (Thr2446) mTOR (Tyr2449) MUC1 (Tyr1218) MUC1 (Tyr1229)
MUC1 iso2 (Tyr227) MUC1 iso2 (Tyr238) MUC1 iso6 (Tyr193) MUC1 iso6 (Tyr204)
MYC MYO1E (Ser980) MYO1E (Ser983) MYO1E (Tyr7)
MYO1E (Tyr9) MYO1E (Tyr971) MYO1E (Tyr974) MYPT1 (Ser888)
MYPT1 (Ser903) MYPT1 (Thr892) MYPT1 (Tyr890) MYPT1 (Tyr911)
MYPT1 (Tyr913) MYST4 (Ser1048) MYST4 iso4 (Ser1048) NF-κB p105 (Ser944)
NF-κB p105 (Thr943) NF-κB p105 (Thr950) Notch1 Notch1 (Ser2136)
NuMA-1 (Tyr1774) Numb (Tyr15) Numb iso2 (Tyr15) Numb iso3 (Tyr15)
NumbL (Tyr56) OSR1 (Ser263) OSR1 (Thr185) OSR1 (Thr189)
P130 Cas (Thr385) P130 Cas (Tyr115) P130 Cas (Tyr128) p38α (Thr180)
p38α (Tyr182) p38α iso2 (Thr180) p38α iso2 (Tyr182) p38δ (Thr180)
p38δ (Tyr182) p38γ (Thr183) p38γa (Tyr185) p53 (Ser392)
p70 S6K (Ser243) p70 S6K (Thr248) p70 S6K (Thr250) p70 S6K (Thr252)
p70 S6K (Thr256) p70 S6K iso2 (Ser220) p70 S6K iso2 (Thr225) p70 S6K iso2 (Thr227)
p70 S6K iso2 (Thr229) p70 S6K iso2 (Thr233) p70 S6Kb (Ser219) p70 S6Kb (Thr226)
p70 S6Kb (Thr228) p90RSK p90RSK (Ser221) p90RSK (Thr225)
p90RSK (Thr573) p90RSK (Tyr220) p90RSK (Tyr228) p90RSK (Tyr576)
p90RSK iso3 (Ser230) p90RSK iso3 (Thr234) p90RSK iso3 (Thr582) p90RSK iso3 (Tyr229)
p90RSK iso3 (Tyr237) p90RSK iso3 (Tyr585) PAK1IP1 (Ser365) PAK6 (Ser132)
PAR-4 (Ser211) PAR-4 (Ser212) PAR-4 (Tyr213) PARD3 (Tyr388)
PARD3 iso10 (Tyr388) PARD3 iso5 (Tyr344) PARP1 PCMT1 (Tyr213)
PCTAIRE1 (Tyr176) PCTAIRE1 iso3 (Tyr250) PCTAIRE2 (Tyr203) PDGF Receptor α
PDGF Receptor α (Ser566) PDGF Receptor α (Ser755) PDGF Receptor α (Ser847) PDGF Receptor α (Tyr1018)
PDGF Receptor α (Tyr572) PDGF Receptor α (Tyr574) PDGF Receptor α (Tyr742) PDGF Receptor α (Tyr754)
PDGF Receptor α (Tyr849) PDK1 (Ser241) PDK1 (Thr245) PDK1 iso4 (Ser114)
PDK1 iso4 (Thr118) PHC3 (Ser616) PHC3 (Thr609) PHC3 (Thr614)
PHC3 (Thr621) PHKA1 (Ser729) PHKA1 (Ser735) PHKA1 (Tyr75)
PHKB (Tyr29) PHKB iso2 (Tyr22) PHKB iso3 (Tyr29) PIK3C2A (Ser409)
PIK3CA (Ser507) PIK3CA (Tyr644) PIK3CB (Tyr425) PIK3R1
PIK3R1 (Tyr467) PIK3R2 PIK3R2 (Tyr464) PIK3R3
PIK3R3 (Tyr199) PIP5K (Tyr1772) PITSLRE (Tyr449) PITSLRE B (Tyr437)
PITSLRE B iso10 (Tyr93) PITSLRE iso12 (Tyr93) PKAR2A (Tyr385) PKCα
PKCα (Thr48) PKCβ PKCβ (Thr48) PKCβ (Thr500)
PKCβ (Thr504) PKCβ iso2 (Thr48) PKCβ iso2 (Thr500) PKCβ iso2 (Thr504)
PKCδ (Ser645) PKCδ (Ser647) PKCδ (Ser654) PKCδ (Ser664)
PKCδ (Tyr646) PKCδ iso13 (Ser645) PKCδ iso13 (Ser647) PKCδ iso13 (Ser654)
PKCδ iso13 (Ser664) PKCδ iso13 (Tyr646) PKCQ PKD2 (Ser375)
PKD2 (Tyr378) PKN1 (Ser916) PKN2 (Ser306) PLCγ1 (Ser1248)
PLCγ1 (Ser470) PLCγ1 (Thr50) PLCγ1 (Tyr472) PLCγ1 iso2 (Ser1249)
PLCγ1 iso2 (Ser470) PLCγ1 iso2 (Thr50) PLCγ1 iso2 (Tyr472) PLEKHA2 (Ser182)
PLEKHA2 (Ser184) PLEKHA2 (Tyr185) PLEKHA5 (Tyr590) PLEKHG4 (Ser677)
PLEKHG4 (Tyr676) PPP1CB PPP1CB (Tyr304) PPP1CB (Tyr306)
PPP2R5D (Tyr451) PRAS40 (Thr246) PRAS40 iso3 (Thr266) PRC1 (Ser513)
PRC1 (Tyr511) PRC1 iso2 (Ser483) PRC1 iso2 (Tyr481) PRC1 iso3 (Ser472)
PRC1 iso3 (Tyr470) PRP4 (Tyr849) PSMC4 PTP-PEST (Tyr88)
PTPN13 (Tyr943) PTPN13 iso3 (Tyr943) PTPRA (Tyr295) PTPRA (Tyr798)
PTPRA iso2 (Tyr286) PTPRA iso2 (Tyr789) PTPRD (Tyr1699) PTPRD iso5 (Tyr1292)
PTPRD iso7 (Tyr1283) PTPRE (Tyr696) PTPRE iso2 (Tyr638) PTPRG (Tyr906)
PTPRG (Tyr911) PTPRJ (Thr339) PTPRK (Tyr940) PTPRM (Tyr953)
PTPRS (Tyr1735) Pyk2 (Tyr579) Pyk2 (Tyr580) Pyk2 iso2 (Tyr579)
Pyk2 iso2 (Tyr580) RAB23 (Ser186) RAB23 (Ser187) RAB23 (Ser188)
RAB23 (Thr184) Rab7 (Tyr183) RABEP1 (Tyr501) RABEP1 iso2 (Tyr501)
Raf1 (Ser338) Raf1 (Ser339) Raf1 (Tyr340) Raf1 (Tyr341)
RAIG1 (Ser321) RAIG1 (Ser345) RAIG1 (Thr322) RAIG1 (Tyr317)
RAIG1 (Tyr347) RAIG1 (Tyr350) Rap1GAP (Thr23) Rap1GAP (Tyr27)
Rap1GAP iso2 (Thr23) Rap1GAP iso2 (Tyr27) Rap1GAP iso3 (Thr54) Rap1GAP iso3 (Tyr58)
Rap1GAP iso5 (Thr87) Rap1GAP iso5 (Tyr91) RAPGEF2 (Ser960) RAPGEF2 iso2 (Ser948)
RAPH1 (Ser822) RAPH1 (Thr830) RAPH1 (Tyr524) RAPH1 (Tyr823)
Rb (Ser773) Rb (Ser780) Rb (Ser788) Rb (Ser794)
Rb (Ser795) Rb (Thr774) Rb (Thr778) Rb (Tyr771)
Rb (Tyr790) RBBP6 (Ser516) RbBP6 iso2 (Ser516) RBM14
RBM14 (Ser215) RBM14 (Ser220) RBM14 (Ser225) RBM14 (Tyr226)
RBM34 (Tyr71) RBM47 (Ser540) RBM47 (Thr533) RBM47 (Thr554)
RBM47 (Tyr537) RBM47 (Tyr541) RBMS2 (Ser277) RBMS2 (Ser280)
RBMS2 (Ser285) RBMS2 (Tyr290) RhoA (Tyr34) RhoA iso3 (Tyr34)
RhoG (Tyr32) RICS (Tyr2048) Rictor (Ser1320) Rictor (Tyr1269)
Rin1 (Thr696) Rin1 (Tyr36) Rin1 (Tyr698) Rin1 (Tyr701)
RIPK1 RIPK2 (Ser176) RPS3A RSK2
RSK2 (Ser227) RSK2 (Thr231) RSK2 (Thr577) RSK2 (Tyr226)
RSK2 (Tyr234) RSK2 (Tyr580) RSK3 RSK4
RSK4 (Ser232) RSK4 (Thr236) RSK4 (Tyr231) RSK4 (Tyr239)
S6 (Ser235) S6 (Ser236) S6 (Ser240) S6 (Ser242)
S6 (Ser244) S6 (Ser246) S6 (Ser247) S6 (Thr241)
SBNO1 (Ser815) SBNO1 (Ser817) SBNO1 (Ser818) SBNO1 (Ser823)
SBNO1 (Ser837) SBNO1 (Thr819) SBNO1 (Thr835) SEC6L1 (Tyr737)
SF3A1 (Ser413) SF3A1 (Ser423) SF3A1 (Thr416) SgK223 (Ser490)
Shb (Tyr268) Shb (Tyr272) SHIP-2 (Tyr886) SHP-1 (Tyr301)
SHP-1 iso5 (Tyr301) SHP-2 (Ser302) SHP-2 (Tyr304) SIPA1L1 (Ser1632)
SIPA1L1 (Tyr1633) SLITRK4 (Tyr811) SLITRK5 (Tyr749) SLITRK5 (Tyr751)
SLK (Tyr1225) SMAD1 Smad1 (Ser462) Smad1 (Ser463)
Smad1 (Ser465) Smad2 Smad3 Smad5
Smad5 (Ser463) Smad5 (Ser465) Smad8 (Ser464) Smad8 (Ser465)
Smad8 (Ser467) Smad9 SMG1 (Ser147) SOS2 (Ser1132)
Src (Tyr419) STAM2 (Ser372) STAM2 (Ser375) STAM2 (Tyr371)
STAM2 (Tyr374) Stat1 Stat3 Stat3 (Ser691)
Stat3 (Ser701) Stat3 (Thr708) Stat3 (Tyr705) Stat3 iso3 (Ser691)
Stat3 iso3 (Ser701) Stat3 iso3 (Thr708) Stat3 iso3 (Tyr705) Stat5A (Tyr694)
Stat5B (Tyr699) Stat6 (Tyr641) STLK3 (Ser309) STLK3 (Thr231)
STLK3 (Thr235) Syk (Tyr525) Syk (Tyr526) TANC2 (Tyr1919)
TANC2 (Tyr1920) TBC1D1 (Ser237) Tec (Tyr228) Tec (Tyr233)
Tensin 1 (Tyr766) TIE1 (Ser472) Timeless (Ser1149) TMOD3 (Tyr86)
TMPO (Ser388) TMPO (Tyr390) TMPO (Tyr394) TMPO iso2 (Ser279)
TMPO iso2 (Tyr281) TMPO iso2 (Tyr285) TPD52L2 TPD52L2 (Ser96)
TPD52L2 (Tyr106) TPX2 (Ser322) TPX2 (Thr323) TPX2 (Thr338)
TPX2 (Tyr324) TSG118 (Tyr255) TSSC4 (Ser143) TSSC4 (Ser146)
TSSC4 (Tyr155) Tyro3 (Tyr681) Tyro3 (Tyr685) Tyro3 (Tyr686)
ULK4 (Thr134) WDR32 (Ser61) WDR32 (Ser63) WNK1 (Thr1963)
WNK1 iso4 (Thr2215) YAP1 (Tyr407) YAP1 iso2 (Tyr391) Yes (Tyr426)
YSK1 (Thr166) YSK1 (Thr168) YSK1 (Thr174) YSK1 (Thr178)
ZAP3 (Ser561) ZAP3 iso4 (Ser756) ZAP-70 (Ser289) ZAP-70 (Ser301)
ZAP-70 (Ser313) ZAP-70 (Ser317) ZAP-70 (Ser320) ZAP-70 (Thr494)
ZAP-70 (Tyr292) ZAP-70 (Tyr315) ZAP-70 (Tyr319) ZAP-70 (Tyr492)
ZAP-70 (Tyr493) ZC3H15 (Ser135) ZC3H15 (Tyr137) ZNF598 (Ser288)
ZNF598 iso2 (Ser288) ZNF828 (Ser405) ZNF828 (Thr403) ZO-1 (Ser1360)
ZO-1 (Tyr1354) ZO-1 (Tyr1355) ZO-1 (Tyr1361) ZO-1 iso2 (Ser1280)
ZO-1 iso2 (Tyr1274) ZO-1 iso2 (Tyr1275) ZO-1 iso2 (Tyr1281) Zyxin (Ser169)
Zyxin (Ser170) Zyxin (Tyr172)    

* The following targets are included as control markers for total protein: β-Actin, Histone H3, GAPDH, and α-Tubulin.

PTMScan® PI3K / Akt Signaling

PTMScan® Direct PI3K/Akt Service allows access to perform targeted screening and quantification of a defined set of protein sites within the or related to the PI3K/ Akt pathway that are critical for drug discovery, biomarker discovery, or diagnostic development. The table below illustrates the list of protein sites that can be monitored with PTMScan® Direct PI3K/Akt Service.

Altogether, the PTMScan® Direct PI3K / Akt service provides a robust method to qualitatively identify and quantitatively profile 296 unique phosphorylation sites to 105 proteins.

PTMScan Direct PI3K/Akt Pathway Coverage.

Sample Case Study Data

Note: The case studies featured below have been saved in Excel (XLS) format.

PI3K / Akt Protein Sites
PI3K / Akt Protein Sites
4E-BP1 (Ser35) 4E-BP1 (Ser44) 4E-BP1 (Thr36) 4E-BP1 (Thr37)
4E-BP1 (Thr41) 4E-BP1 (Thr45) 4E-BP1 (Thr46) 4E-BP1 (Thr50)
4E-BP1 (Tyr34) 4E-BP1 (Tyr54) 4E-BP2 (Ser44) 4E-BP2 (Thr36)
4E-BP2 (Thr37) 4E-BP2 (Thr41) 4E-BP2 (Thr45) 4E-BP2 (Thr46)
4E-BP2 (Thr50) 4E-BP2 (Tyr34) 4E-BP2 (Tyr54) 4E-BP3 (Thr23)
4E-BP3 (Thr27) 4E-BP3 (Thr31) 4E-BP3 (Thr32) ACTB (Thr201)
ACTG1 (Thr201) Akt1 (Ser473) Akt1 (Thr305) Akt1 (Thr308)
Akt1 (Thr312) Akt1 (Tyr315) Akt2 (Ser474) Akt2 (Ser476)
Akt2 (Ser478) Akt2 (Thr309) Akt2 (Thr313) Akt2 (Tyr316)
Akt2 (Tyr475) Akt3 (Ser472) Akt3 (Ser474) Akt3 (Ser476)
Akt3 (Thr298) Akt3 (Thr305) Akt3 (Tyr473) ATR (Ser435)
ATR (Ser436) BAD (Ser71) BAD (Ser74) BAD (Ser75)
BAD (Ser91) BAD (Ser97) BAD (Ser99) BAD (Thr80)
BAD (Tyr76) CTNND1 iso3 (Ser168) CTNND1 iso3 (Thr147) CTNND1 iso3 (Thr149)
CTNND1 iso3 (Thr152) CTNND1 iso4 (Ser168) CTNND1 iso4 (Thr147) CTNND1 iso4 (Thr149)
CTNND1 iso4 (Thr152) CTNND1 (Ser168) CTNND1 (Thr147) CTNND1 (Thr149)
CTNND1 (Thr152) DNMT1 iso2 (Ser748) DNMT1 (Ser732) Dok1 (Tyr341)
Dok2 (Tyr299) eIF4H (Ser230) eIF4H (Thr217) eIF4H (Thr220)
EphA2 (Thr593) EphA2 (Thr771) EphA2 (Thr773) EphA2 (Thr774)
EphA2 (Tyr588) EphA2 (Tyr772) FAK iso2 (Ser211) FAK iso2 (Ser422)
FAK iso2 (Thr227) FAK iso2 (Tyr216) FAK iso2 (Tyr424) FAK iso2 (Tyr425)
FAK (Ser392) FAK (Ser574) FAK (Thr408) FAK (Tyr397)
FAK (Tyr576) FAK (Tyr577) FOXK1 (Thr273) FOXO1A (Ser256)
FOXO3A (Ser43) FOXO3A (Ser48) FOXO3A (Ser55) FOXO3A (Thr51)
Fyn iso2 (Tyr417) Fyn (Tyr420) GAPDH (Thr153) GOLGA3 (Ser1430)
GOLGA3 (Ser983) GOLGA4 (Ser40) GOLGA4 (Ser41) GOLGA4 (Thr39)
GOLGA4 (Thr43) GSK3A (Ser20) GSK3A (Ser21) GSK3A (Ser39)
GSK3A (Ser41) GSK3A (Thr19) GSK3A (Thr46) HGK iso5 (Ser908)
HGK iso5 (Thr187) HGK iso5 (Thr910) HGK iso7 (Ser463) HGK iso7 (Ser934)
HGK iso7 (Thr127) HGK iso7 (Thr936) HGK (Ser523) HGK (Ser913)
HGK (Thr187) HGK (Thr915) HRas (Tyr32) HRas (Tyr64)
IRS1 (Ser303) IRS1 (Ser307) IRS1 (Ser312) IRS1 (Ser315)
IRS1 (Ser323) IRS1 (Ser603) IRS1 (Ser604) IRS1 (Ser616)
IRS1 (Thr305) IRS1 (Thr309) IRS1 (Thr311) IRS1 (Thr608)
IRS1 (Tyr1179) IRS1 (Tyr612) IRS2 (Ser594) IRS2 (Tyr598)
KHSRP (Ser132) KRas iso2 (Tyr32) KRas iso2 (Tyr64) KRas (Tyr32)
KRas (Tyr64) lamin A/C iso2 (Ser404) lamin A/C iso2 (Ser406) lamin A/C (Ser404)
lamin A/C (Ser406) Lck (Tyr394) LOC647000 (Ser41) MEK1 (Ser218)
MEK1 (Ser222) MEK1 (Thr226) MEK2 (Ser222) MEK2 (Ser226)
MEK2 (Thr230) MINK iso4 (Thr187) MINK (Thr187) MST3 iso2 (Thr170)
MST3 iso2 (Thr172) MST3 iso2 (Thr178) MST3 iso2 (Thr182) MST3 (Thr182)
MST3 (Thr184) MST3 (Thr190) MST3 (Thr194) MST4 (Thr320)
MST4 (Thr327) mTOR (Ser2442) mTOR (Ser2448) mTOR (Ser2450)
mTOR (Ser2454) mTOR (Ser2478) mTOR (Ser2481) mTOR (Thr2444)
mTOR (Thr2446) mTOR (Thr2471) mTOR (Thr2473) mTOR (Thr2474)
mTOR (Tyr2449) MYPT1 (Ser802) MYPT1 (Ser910) MYPT1 (Thr453)
MYPT1 (Tyr446) MYPT1 (Tyr766) MYPT1 (Tyr901) MYPT1 (Tyr911)
NDRG1 (Ser344) NDRG1 (Ser352) NDRG1 (Ser354) NDRG1 (Ser357)
NDRG1 (Ser362) NDRG1 (Ser364) NDRG1 (Ser367) NDRG1 (Ser378)
NDRG1 (Ser384) NDRG1 (Ser389) NDRG1 (Ser393) NDRG1 (Thr346)
NDRG1 (Thr356) NDRG1 (Thr360) NDRG1 (Thr366) NDRG1 (Thr375)
NF-GMB iso2 (Ser134) NF-GMB iso2 (Tyr131) NF-GMB (Ser134) NF-GMB (Tyr131)
NF-κB p105 (Ser907) NRas (Tyr32) NRas (Tyr64) Nur77 (Ser351)
Nur77 (Ser360) PAK2 (Ser19) PAK2 (Ser20) PAK2 (Ser32)
PAK2 (Ser36) PAK2 (Ser42) PAK2 (Thr21) PAK2 (Thr25)
PAR-4 (Ser231) PAR-4 (Ser233) PAR-4 (Thr229) PAR-4 (Tyr177)
PDK1 iso2 (Ser114) PDK1 (Ser241) PDPK2 (Ser214) PIK3CA (Ser507)
PIK3CA (Ser509) PIK3R1 (Tyr467) PIK3R2 (Tyr464) PIK3R3 (Tyr199)
PIK3R5 (Ser507) PIK4CB iso2 (Ser256) PIK4CB (Ser256) PKA RI-α (Ser375)
PKCα (Thr494) PKCα (Thr497) PKCα (Tyr504) PKCβ iso2 (Thr498)
PKCβ iso2 (Thr500) PKCβ (Thr498) PKCβ (Thr500) PKCI (Thr412)
PKD2 (Ser375) PRAS40 (Ser203) PRAS40 (Thr266) PTEN (Ser385)
RANBP3 iso3 (Ser57) RANBP3 iso3 (Ser58) RANBP3 iso3 (Thr56) RANBP3 iso3 (Thr60)
RANBP3 (Ser125) RANBP3 (Ser126) RANBP3 (Thr124) RANBP3 (Thr128)
Raptor (Ser719) Raptor (Ser722) Rictor (Ser1320) RSK2 (Ser386)
S6 (Ser235) S6 (Ser236) S6 (Ser240) S6 (Ser242)
S6 (Ser244) S6 (Ser246) S6 (Ser247) S6 (Thr241)
SGK3 (Ser315) SGK3 (Thr318) Shb (Ser323) Shb (Tyr336)
SHIP-2 (Tyr886) Src (Tyr419) TUBA1A (Ser287) TUBA1B (Ser287)
TUBA3C (Ser287) TUBA3D (Ser287) TUBA3E (Ser287) TUBA4A (Ser287)
TUBB2A (Ser339) TUBB2B (Ser339) TUBB2C (Ser339) TUBB3 (Ser339)
TUBB4 (Ser339) TUBB6 (Ser339) TUBB (Ser339) XIAP (Ser123)
YB-1 (Ser102) YB-1 (Thr108) YB-1 (Tyr99) Yes (Tyr426)
YSK1 (Thr166) YSK1 (Thr168) YSK1 (Thr174) YSK1 (Thr178)

PTMScan® Direct Apoptosis & Autophagy

PTMScan® Direct Apoptosis / Autophagy Service allows access to perform targeted screening and quantification of a defined set of protein sites within the or related to the Apoptosis or Autophagy pathways that are critical for drug discovery, biomarker discovery, or diagnostic development. The table below illustrates the list of protein sites that can be monitored with PTMScan® Direct Apoptosis / Autophagy Service.

Altogether, the PTMScan® Direct Apoptosis / Autophagy service provides a robust method to qualitatively identify and quantitatively profile 175 unique sites of phosphorylation and caspase cleavage on 100 proteins.

PTMScan Direct Apoptosis or Autophagy Pathway Coverage.

Sample Case Study Data

Note: The case studies featured below have been saved in Excel (XLS) format.

Apoptosis / Autophagy Protein Sites
Apoptosis / Autophagy Protein Sites
α-Tubulin Akt1 Akt1 (Ser473) Akt1 (Ser477)
Akt1 (Thr305) Akt1 (Thr308) Akt1 (Thr312) Akt1 (Thr479)
Akt1 (Tyr315) Akt1 (Tyr474) Akt2 (Ser302) Akt2 (Thr306)
Akt2 (Thr309) Akt2 (Thr313) Akt2 (Tyr316) Akt3 (Ser472)
Akt3 (Ser474) Akt3 (Ser476) Akt3 (Thr302) Akt3 (Thr305)
Akt3 (Thr309) Akt3 (Tyr473) ANXA5 API5
ARC ATG12 ATG12 (Ser41) ATG12 (Thr30)
ATG3 ATG4C ATG7 ATG9A
β-Actin BAD (Ser97) BAD (Ser99) Bak1
Bcl-11B Bcl-9L Bcl-9L (Thr1370) Bcl-xL
Bid BIRC6 Casp2 Casp3
Casp3 (Asp175) Casp3 (Ser176) Casp6 Casp6 (Asp179)
Casp7 Casp7 (Asp198) Casp7 (Ser199) Casp8 (Asp374)
Casp9 Casp9 (Asp315) Casp9 (Ser302) Casp9 (Ser307)
CCAR1 CCDC72 CIAPIN1 CLU
CYC1 CYCS DBC-1 DBC-1 (Ser124)
DDAH2 DNA-PK ERK1 (Thr198) ERK1 (Thr202)
ERK1 (Tyr204) ERK2 (Thr181) ERK2 (Thr185) ERK2 (Thr190)
ERK2 (Tyr187) Fas Fas (Asp269) FYCO1
G6PI GAPDH GRP94 GSK3A (Thr19)
H3 HELLS IκBα (Ser32) IκBα (Ser36)
IκBα (Tyr42) IκBε (Ser18) IκBε (Ser22) IκBε (Ser25)
IKKβ Jun (Ser58) Jun (Ser63) Jun (Ser73)
Jun (Thr62) JunD (Ser100) JunD (Ser90) LDH-A
MIF MMRP19 mTOR mTOR (Ser2478)
mTOR (Ser2481) mTOR (Thr2471) mTOR (Thr2473) mTOR (Thr2474)
Myc NF-κB p105 NF-κB p105 (Ser923) NF-κB p105 (Ser927)
NF-κB p105 (Ser932) NF-κB p65 NF-κB p65 (Asp512) NF-κB p65 (Ser536)
Nik (Thr764) Nudt2 p400 PAR-4 (Asp131)
PARP1 PDCD10 PDCD5 PDCD8
PDCL3 PHLDA1 PI4K2A (Thr76) PIK3C2A
PIK3C3 PIK3CA PIK3CA (Ser507) PIK3CA (Tyr508)
PIK3CB PIK3CD PIK4CA PIP5K2A
PKCA PKCA (Thr494) PKCA (Thr501) PKCB
PKCB (Thr497) PKCB (Thr500) PKCB (Thr504) PKCB (Tyr507)
PKCH PKCT (Thr275) PKD1 (Ser473) PKD1 (Ser738)
PKD2 (Ser706) PKD3 (Ser731) PRAS40 PRAS40 (Ser203)
PRAS40 (Thr266) RABGAP1 Raptor Raptor (Ser877)
Raptor (Ser886) Raptor (Thr883) Raptor (Thr889) Rictor
ROCK1 ROCK2 RUSC1 SH3GLB1
SH3GLB2 SHP-2 SHP-2 (Ser580) SHP-2 (Tyr584)
SOD1 STAG1 Survivin Survivin (Asp72)
TNF-R1 ULK1 (Ser556) ULK4 (Thr645) XIAP
ZNF768 (Ser17) ZNF768 (Ser18) ZNF768 (Ser23)  

PTMScan® Direct Cell Cycle & DNA Damage

PTMScan® Direct Cell Cycle and DNA Damage Service allows access to perform targeted screening and quantification of a defined set of protein sites within the relevant DNA damage and cell cycle control pathways that are critical for drug discovery, biomarker discovery, or diagnostic development. The table below illustrates the list of protein sites that can be monitored with PTMScan® Direct Cell Cycle and DNA Damage Service.

Altogether, the PTMScan® Direct Cell Cycle & DNA Damage service provides a robust method to qualitatively identify and quantitatively profile 168 unique phosphorylation sites to 263 proteins.

PTMScan Direct Cell Cycle & DNA Damage Pathway Coverage.

Sample Case Study Data

Note: The case studies featured below have been saved in Excel (XLS) format.

Cell Cycle & DNA Damage Protein Sites
Cell Cycle & DNA Damage Protein Sites
53BP1 53BP1 (Ser265) α-tubulin APE1
ATM ATM (Ser1981) ATM (Ser1983) ATR
ATR (Ser428) ATRIP AurA (Thr287) AurA (Thr288)
AurA (Thr292) AurB AurB (Thr232) AurB (Thr236)
AurB (Tyr239) AurC (Thr198) AurC (Thr202) AurC (Tyr205)
β-Actin BLM BLM (Ser74) BRCA2 (Thr77)
Bub3 Bub3 (Ser135) Bub3 (Thr133) CBP
CCND1 (Thr286) CCND1 (Thr288) CCNE1 CCNK iso3
CCNL1 (Ser372) CCNL1 (Ser374) CCNL1 (Tyr376) CCNT1 (Ser626)
CCNYL1 CDC123 Cdc16 Cdc23
Cdc25B Cdc25C Cdc25C (Ser191) Cdc25C (Ser198)
Cdc27 Cdc37 Cdc42 CDC45L
CDCA7 (Thr213) CDK1 CDK1 (Thr14) CDK1 (Tyr15)
CDK1 (Tyr19) CDK10 CDK11 CDK2
CDK2 (Thr14) CDK2 (Tyr15) CDK3 CDK3 (Thr14)
CDK3 (Tyr15) CDK4 CDK5 (Tyr15) CDK6
CDK7 CDK8 CHED (Ser1054) CHED (Ser1065)
CHED (Ser1066) CHED (Thr1056) CHED (Thr1058) Chk1
Chk1 (Ser296) Chk1 (Ser307) Chk1 (Ser308) Chk1 (Ser315)
Chk1 (Ser316) Chk1 (Ser317) Chk1 (Ser345) Chk1 (Ser357)
Chk1 (Thr348) Chk1 (Tyr314) Chk2 Chk2 (Ser379)
DDB1 DNA-PK DNA-PK (Ser3205) ERK1
ERK1 (Thr202) ERK1 (Tyr204) ERK2 ERK2 (Thr185)
ERK2 (Tyr187) ERK5 (Thr219) ERK5 (Tyr221) FANCB
FANCD2 FANCI GAPDH H2AX
H2AX (Ser140) H2AX (Thr137) H3 JNK1 (Thr183)
JNK1 (Tyr185) JNK2 (Thr183) JNK2 (Thr188) JNK2 (Tyr185)
JNK3 (Thr221) JNK3 (Tyr223) Ku70 Ku80
LOC651610 LOC731751 (Ser3204) MCM2 MCM3
MCM4 MCM5 MCM6 MCM7
MKK3 (Ser253) MKK4 (Ser257) MLH1 MRE11A
MSH2 (Ser717) MSH6 (Ser309) MST1 (Ser40) MST1 (Ser43)
Myt1 (Ser40) NBS1 NPM1 (Ser125) NUCKS
NUCKS (Ser14) NUCKS (Ser181) NUCKS (Ser19) NuMA-1
NuMA-1 (Ser1772) NuMA-1 (Ser395) NuMA-1 (Thr1776) p300
p21Cip1 p21Cip1 (Ser130) p27Kip1 p27Kip1 (Ser175)
p27Kip1 (Ser178) p27Kip1 (Ser183) p27Kip1 (Thr170) p27Kip1 (Thr187)
p38α (Ser61) p38α (Thr175) p38α (Thr180) p38α (Tyr182)
p38δ (Thr180) p38δ (Tyr182) p38γ (Ser180) p38γ (Thr183)
p38γ (Tyr185) p53 (Ser392) p70S6K (Ser243) p70S6K (Thr248)
p70S6K (Thr250) p70S6K (Thr252) p70S6K (Thr256) p70S6Kb (Ser219)
p70S6Kb (Ser356) p70S6Kb (Thr226) p70S6Kb (Thr228) p70S6Kb (Thr232)
p90RSK p90RSK (Ser221) p90RSK (Thr225) p90RSK (Tyr220)
PARP1 (Ser179) PCNA PCTAIRE1 (Tyr176) PCTAIRE2 (Tyr203)
PITSLRE (Tyr449) PITSLRE B (Tyr437) PMS2 (Ser425) POLA
POLD1 POLD2 PRC1 (Ser500) PRC1 (Ser501)
PRC1 (Ser513) PRC1 (Ser516) PRC1 (Thr509) PRC1 (Tyr511)
Profilin-1 Profilin-2 Rad17 RAD21
RAD21L1 RAD23A RAD23B RAD54B
RAD54B (Ser867) RAD54B (Ser869) Rb Rb (Ser773)
Rb (Ser780) Rb (Ser788) Rb (Ser794) Rb (Ser795)
Rb (Ser807) Rb (Ser811) Rb (Ser816) Rb (Thr774)
Rb (Thr778) Rb (Thr821) Rb (Thr823) Rb (Thr826)
Rb (Tyr790) Rb (Tyr805) Rb (Tyr813) RBBP4
RBBP7 RCC1 RFA2 RFC1 (Ser923)
RFC2 RFC3 RFC4 RFC5
RhoQ RPA1 RPA3 RRas
RSK2 RSK2 (Ser227) RSK2 (Thr231) RSK2 (Tyr226)
RSK3 RSK4 RSK4 (Ser232) RSK4 (Thr236)
RSK4 (Tyr231) Smad5 (Ser57) Smad5 (Ser58) Smc5
Smc5 (Ser792) Smc5 (Ser793) SMG1 (Ser111) SMG1 (Ser121)
SMG1L (Ser111) SMG1L (Ser121) tau (Ser713) tau (Ser717)
tau (Ser721) tau (Thr720) tau (Tyr711) TOP2A
TOP2B TOPBP1 XPG (Ser324) XPG (Ser697)
XPG (Ser699) XRCC1 XRCC1 (Ser241) ZNF828 (Ser405)
ZNF828 (Ser505) ZNF828 (Ser507) ZNF828 (Thr403)  

PTMScan® Ser/Thr Kinases

PTMScan® Direct Ser/Thr Kinases Service allows access to perform targeted screening and quantification of a defined set of protein sites within the Ser/Thr kinome critical for drug discovery, biomarker discovery, or diagnostic development. PTMScan Direct Ser/Thr Kinases Service provides kinome-wide assessment of Ser/Thr phosphorylation. The table below illustrates the list of protein sites that can be monitored with PTMScan® Direct Ser/Thr Kinases Service.

Altogether, the PTMScan® Direct Serine/Threonine Kinase service provides a robust method to qualitatively identify and quantitatively profile 385 unique phosphorylation sites to 130 proteins.

Highlighted Ser/Thr Nodes in the Human Kinome

Sample PowerPoint Summary Report

PTMScan Sample Report Icon

Sample PowerPoint Summary Report  2.0 MB

Ser/Thr Protein Sites
Ser/Thr Protein Sites
β-Actin* Akt1 (Ser473) Akt1 (Ser475) Akt1 (Thr305)
Akt1 (Thr308) Akt1 (Thr312) Akt1 (Thr479) Akt1 (Tyr315)
Akt1 (Tyr474) Akt2 (Ser302) Akt2 (Ser474) Akt2 (Ser476)
Akt2 (Ser478) Akt2 (Thr306) Akt2 (Thr309) Akt2 (Thr313)
Akt2 (Tyr316) Akt2 (Tyr475) Akt3 (Ser472) Akt3 (Ser474)
Akt3 (Ser476) Akt3 (Thr302) Akt3 (Thr305) Akt3 (Thr309)
Akt3 (Tyr473) AMPKα1 (Ser172) AMPKα1 (Ser176) AMPKα1 (Ser184)
AMPKα1 (Ser187) AMPKα1 (Ser486) AMPKα1 (Ser494) AMPKα1 (Ser496)
AMPKα1 (Thr183) AMPKα1 (Thr482) AMPKα1 (Thr488) AMPKα1 (Thr490)
AMPKα2 (Ser161) AMPKα2 (Ser165) AMPKα2 (Ser173) AMPKα2 (Ser176)
AMPKα2 (Thr172) ASK1 (Thr916) ASK1 (Thr918) ATM (Ser1981)
ATM (Ser1983) Aurora A (Thr287) Aurora A (Thr288) Aurora A (Thr292)
Aurora B (Thr232) Aurora B (Thr236) Aurora C (Thr198) Aurora C (Thr202)
Bcr (Tyr177) BMPR2 (Thr977) BMPR2 (Tyr979) Brd2 (Ser253)
Brd2 (Ser256) Brd4 (Thr942) CDK1 (Thr14) CDK1 (Tyr15)
CDK1 (Tyr19) CDK2 (Thr14) CDK2 (Tyr15) CDK2 (Tyr19)
CDK3 (Thr14) CDK3 (Tyr15) CDK3 (Tyr19) CDK5 (Tyr15)
CDK6 (Tyr24) ChaK1 (Ser1404) ChaK1 (Ser1407) CHED (Ser1225)
CHED (Ser1229) CHED (Thr1226) Chk1 (Ser296) Chk1 (Ser305)
Chk1 (Ser307) Chk1 (Ser315) Chk1 (Ser316) Chk1 (Ser317)
Chk1 (Ser343) Chk1 (Ser345) Chk1 (Ser357) Chk1 (Thr348)
Chk1 (Thr362) Chk1 (Tyr314) CKB (Thr35) CLK3 (Ser157)
CLK3 (Ser165) CLK3 (Tyr155) CLK3 (Tyr163) CLK3 (Tyr166)
CRK7 (Thr1244) CRK7 (Thr1246) dCK (Ser13) Erk1 (Thr202)
Erk1 (Thr207) Erk1 (Tyr204) Erk2 (Thr185) Erk2 (Thr190)
Erk2 (Tyr187) Erk3 (Ser363) Erk3 (Tyr357) Erk5 (Thr218)
Erk5 (Tyr220) GAPDH* GCN2 (Ser254) GCN2 (Ser258)
GCN2 (Ser261) GCN2 (Ser264) GCN2 (Ser274) GCN2 (Tyr253)
GCN2 (Tyr269) GSK-3α (Ser20) GSK-3α (Ser21) GSK-3α (Thr19)
GSK-3β (Ser13) GSK-3β (Ser25) GSK-3β (Ser9) GSK-3β (Thr8)
HGK (Ser264) HGK (Thr187) HKDC1 (Ser155) HKDC1 (Thr153)
Histone H3* ICK (Thr157) ICK (Tyr159) IKKε (Ser172)
KSR (Ser265) KSR (Thr268) KSR (Thr272) KSR2 (Thr269)
KSR2 (Thr276) LOC100133591 (Ser223) LOC651610 (Ser1859) LOC651610 (Ser1861)
LRRK1 (Thr30) LRRK2 (Ser961) MAPKAPK-2 (Thr221) MAPKAPK-2 (Thr222)
MAPKAPK-2 (Thr317) MAPKAPK-2 (Thr329) MAPKAPK-2 (Thr334) MAPKAPK-2 (Thr338)
MAPKAPK-2 (Tyr225) MAPKAPK-3 (Ser307) MAPKAPK-3 (Thr313) MAPKAPK-3 (Thr317)
MARK1 (Thr504) MARK2 (Ser592) MARK2 (Ser593) MARK2 (Ser595)
MARK2 (Thr596) MARK3 (Thr530) MEK1 (Ser218) MEK1 (Ser222)
MEK1 (Thr226) MEK2 (Ser222) MEK2 (Ser226) MEK2 (Thr230)
MINK (Thr187) MKK3 (Ser212) MKK3 (Ser218) MKK3 (Ser253)
MKK3 (Thr222) MKK3 (Tyr214) MKK3 (Tyr230) MKK4 (Ser257)
MKK4 (Thr261) MKK6 (Ser201) MKK6 (Ser207) MKK6 (Thr211)
MSK1 (Ser376) MSK1 (Ser381) MSK1 (Tyr375) MSK2 (Ser360)
MSK2 (Ser365) MSK2 (Ser634) MSK2 (Thr376) MSK2 (Tyr359)
Mst1 (Ser40) Mst1 (Ser43) Mst1 (Tyr41) Mst3 (Thr182)
Mst3 (Thr184) Mst3 (Thr190) Mst3 (Thr194) Mst4 (Thr178)
Mst4 (Thr182) mTOR (Ser178) mTOR (Ser2442) mTOR (Ser2448)
mTOR (Ser2450) mTOR (Ser2454) mTOR (Thr2444) mTOR (Thr2446)
mTOR (Tyr2449) NDK7 (Ser304) NDK7 (Thr300) NDK7 (Thr318)
NDK7 (Tyr303) NDR1 (Thr444) NDR1 (Tyr445) NDR2 (Thr442)
NDR2 (Tyr443) OSR1 (Thr185) OSR1 (Thr189) p38α (Thr175)
p38α (Thr180) p38α (Tyr182) p38γ (Thr183) p38γ (Tyr185)
p38δ (Thr180) p38δ (Tyr182) p70 S6 Kinase (Ser243) p70 S6 Kinase (Ser441)
p70 S6 Kinase (Ser447) p70 S6 Kinase (Ser452) p70 S6 Kinase (Thr248) p70 S6 Kinase (Thr250)
p70 S6 Kinase (Thr252) p70 S6 Kinase (Thr444) p70 S6 Kinase β (Ser219) p70 S6 Kinase β (Thr226)
p70 S6 Kinase β (Thr228) p90RSK (Ser221) p90RSK (Ser380) p90RSK (Thr225)
p90RSK (Tyr220) PAK4 (Ser474) PAK4 (Thr207) PAK4 (Thr478)
PAK5 (Ser602) PAK6 (Ser560) PCTAIRE1 (Ser138) PCTAIRE1 (Tyr176)
PCTAIRE2 (Tyr203) PDK1 (Ser241) PDK1 (Thr245) PDK1 (Tyr248)
PDPK2 (Ser214) PDPK2 (Thr218) PDPK2 (Tyr221) PHKA2 (Ser1015)
PHKA2 (Ser1022) PHKA2 (Ser691) PI3 Kinase p110-alpha (Ser507) PITSLRE B (Tyr437)
PITSLRE (Thr595) PITSLRE (Tyr449) PKA C-α (Thr196) PKA C-α (Thr198)
PKA C-α (Thr202) PKA C-β (Thr196) PKA C-β (Thr198) PKA C-β (Thr202)
PKA C-γ (Thr196) PKA C-γ (Thr198) PKA C-γ (Thr202) PKCα (Ser226)
PKCα (Ser657) PKCα (Thr494) PKCα (Thr495) PKCα (Thr497)
PKCα (Thr501) PKCα (Tyr504) PKCβ (Thr497) PKCβ (Thr500)
PKCβ (Thr504) PKCδ (Ser304) PKCδ (Ser506) PKCδ (Ser645)
PKCδ (Ser647) PKCδ (Ser654) PKCδ (Ser658) PKCδ (Ser664)
PKCδ (Thr507) PKCδ (Thr511) PKCδ (Tyr313) PKCδ (Tyr334)
PKCδ (Tyr514) PKCδ (Tyr646) PKCε (Ser729) PKCγ (Thr510)
PKCγ (Thr511) PKCγ (Thr514) PKCγ (Thr518) PKCι (Ser411)
PKCι (Thr409) PKCι (Thr410) PKCι (Thr412) PKCι (Thr416)
PKCθ (Thr307) PKCζ (Ser409) PKCζ (Thr407) PKCζ (Thr410)
PKM2 (Ser77) PKN1 (Ser495) PKN1 (Ser773) PKN1 (Thr772)
PKN1 (Thr774) PKN1 (Tyr768) PKN2 (Ser497) PKN2 (Ser815)
PKN2 (Thr814) PKN2 (Thr816) PKN2 (Thr820) PKN2 (Tyr810)
PKN3 (Thr718) PLK1 (Thr210) PLK1 (Thr214) PRP4 (Ser852)
PRP4 (Tyr849) PRPS1 (Ser314) PRPS1L1 (Ser314) PRPS2 (Ser314)
PYGB (Ser15) PYGB (Tyr263) A-Raf (Ser299) A-Raf (Tyr296)
A-Raf (Tyr301) A-Raf (Tyr302) B-Raf (Ser446) B-Raf (Ser447)
B-Raf (Thr440) Raf1 (Ser338) Raf1 (Ser339) Raf1 (Tyr340)
Raf1 (Tyr341) RIOK2 (Ser332) RIOK2 (Ser335) RIOK2 (Tyr366)
RIPK2 (Ser539) RSK2 (Ser227) RSK2 (Ser386) RSK2 (Thr231)
RSK2 (Tyr226) RSK4 (Ser232) RSK4 (Thr236) RSK4 (Tyr231)
JNK1 (Ser179) JNK1 (Thr183) JNK1 (Thr188) JNK1 (Tyr185)
JNK2 (Thr183) JNK2 (Thr188) JNK2 (Tyr185) JNK3 (Ser217)
JNK3 (Thr221) JNK3 (Thr226) JNK3 (Tyr223) SGK1 (Ser74)
SGK1 (Ser78) SGK1 (Ser80) SGK2 (Thr251) SGK2 (Thr253)
SgK223 (Thr203) SGK3 (Thr320) SGK3 (Thr324) smMLCK (Thr276)
SPEG (Ser378) SPEG (Ser381) SPEG (Thr375) SPAK (Thr233)
SPAK (Thr237) TAO1 (Ser181) TAO1 (Thr185) TAO2 (Ser181)
TAO3 (Ser177) TAO3 (Thr181) TBK1 (Ser172) TIF1β (Ser459)
TIF1β (Ser460) TIF1β (Tyr458) TNIK (Thr187) TTK (Thr33)
α-Tubulin* ULK1 (Ser556) WNK1 (Ser1959) YSK1 (Thr166)
YSK1 (Thr168) YSK1 (Thr174) YSK1 (Thr178) ZAK (Ser591)
ZAK (Ser610) ZAK (Ser648) ZAK (Ser649) ZAK (Thr576)
ZAK (Thr742)      

* The following targets are included as control markers for total protein: β-Actin, Histone H3, GAPDH, and α-Tubulin.

PTMScan® Tyrosine Kinase

PTMScan® Direct Tyrosine Kinases Service allows access to perform targeted screening and quantification of a defined set of protein sites within the tyrosine kinase branch of the kinome that are critical for drug discovery, biomarker discovery, or diagnostic development. The table below illustrates the list of protein sites that can be monitored with PTMScan® Direct Tyrosine Kinases Service.

Altogether, the PTMScan® Direct Tyrosine Kinase service provides a robust method to qualitatively identify and quantitatively profile 671 unique phosphorylation sites to 120 proteins.

PTMScan Tyrosine Kinome Coverage.

Sample Case Study Data

Note: The case studies featured below have been saved in Excel (XLS) format.

Tyrosine Protein Sites
Tyrosine Protein Sites
A6 iso2 (Tyr343) A6 (Tyr309) Abl iso2 (Tyr112) Abl iso2 (Tyr134)
Abl iso2 (Tyr147) Abl iso2 (Tyr158) Abl iso2 (Tyr191) Abl iso2 (Tyr204)
Abl iso2 (Tyr245) Abl iso2 (Tyr251) Abl iso2 (Tyr272) Abl iso2 (Tyr276)
Abl iso2 (Tyr283) Abl iso2 (Tyr412) Abl iso2 (Tyr432) Abl iso2 (Tyr488)
Abl (Tyr115) Abl (Tyr128) Abl (Tyr139) Abl (Tyr172)
Abl (Tyr185) Abl (Tyr215) Abl (Tyr226) Abl (Tyr232)
Abl (Tyr253) Abl (Tyr257) Abl (Tyr264) Abl (Tyr393)
Abl (Tyr413) Abl (Tyr469) Abl (Tyr93) Ack iso3 (Tyr596)
Ack iso3 (Tyr937) Ack iso3 (Tyr938) Ack iso3 (Tyr946) Ack (Tyr284)
Ack (Tyr518) Ack (Tyr859) Ack (Tyr860) Ack (Tyr868)
Ack (Tyr872) Ack (Tyr874) ALK (Tyr1078) ALK (Tyr1092)
ALK (Tyr1096) ALK (Tyr1131) ALK (Tyr1278) ALK (Tyr1282)
ALK (Tyr1283) ALK (Tyr1359) ALK (Tyr1507) ALK (Tyr1584)
ALK (Tyr1586) ALK (Tyr1604) Arg iso4 (Tyr125) Arg iso4 (Tyr403)
Arg (Tyr161) Arg (Tyr174) Arg (Tyr310) Arg (Tyr439)
Arg (Tyr683) Arg (Tyr718) Arg (Tyr719) Axl (Tyr696)
Axl (Tyr697) Axl (Tyr698) Axl (Tyr702) Axl (Tyr703)
Axl (Tyr726) Axl (Tyr755) Axl (Tyr759) Axl (Tyr866)
Blk (Tyr181) Blk (Tyr182) Blk (Tyr187) Blk (Tyr188)
Blk (Tyr389) Blk (Tyr494) Blk (Tyr501) Brk (Tyr114)
Brk (Tyr447) Btk (Tyr223) Btk (Tyr225) Btk (Tyr334)
Btk (Tyr344) Btk (Tyr361) Btk (Tyr375) Btk (Tyr511)
Btk (Tyr551) CCK4 (Tyr872) CLK3 (Tyr163) CSFR (Tyr556)
CSFR (Tyr699) CSFR (Tyr809) CSK (Tyr263) DDR1 (Tyr484)
DDR1 (Tyr513) DDR1 (Tyr520) DDR1 (Tyr790) DDR1 (Tyr792)
DDR1 (Tyr794) DDR1 (Tyr796) DDR1 (Tyr797) DDR1 (Tyr869)
DDR1 (Tyr881) DDR2 (Tyr471) DDR2 (Tyr481) DDR2 (Tyr521)
DDR2 (Tyr735) DDR2 (Tyr736) DDR2 (Tyr739) DDR2 (Tyr740)
DDR2 (Tyr741) DYRK1A iso2 (Tyr136) DYRK1A iso2 (Tyr312) DYRK1A iso4 (Tyr145)
DYRK1A iso4 (Tyr321) DYRK1A (Tyr145) DYRK1A (Tyr321) DYRK1B (Tyr273)
DYRK2 (Tyr382) DYRK3 (Tyr369) DYRK4 (Tyr264) EGFR (Tyr1016)
EGFR (Tyr1069) EGFR (Tyr1092) EGFR (Tyr1110) EGFR (Tyr1125)
EGFR (Tyr1138) EGFR (Tyr1172) EGFR (Tyr1197) EGFR (Tyr727)
EGFR (Tyr827) EGFR (Tyr869) EGFR (Tyr998) EphA1 (Tyr599)
EphA1 (Tyr605) EphA1 (Tyr781) EphA2 (Tyr575) EphA2 (Tyr588)
EphA2 (Tyr589) EphA2 (Tyr594) EphA2 (Tyr595) EphA2 (Tyr628)
EphA2 (Tyr694) EphA2 (Tyr735) EphA2 (Tyr772) EphA2 (Tyr773)
EphA2 (Tyr921) EphA2 (Tyr922) EphA2 (Tyr930) EphA2 (Tyr960)
EphA3 (Tyr123) EphA3 (Tyr124) EphA3 (Tyr596) EphA3 (Tyr602)
EphA3 (Tyr736) EphA3 (Tyr779) EphA3 (Tyr937) EphA4 (Tyr596)
EphA4 (Tyr602) EphA4 (Tyr779) EphA4 (Tyr798) EphA5 (Tyr650)
EphA5 (Tyr656) EphA5 (Tyr672) EphA5 (Tyr790) EphA5 (Tyr833)
EphA6 (Tyr787) EphA6 (Tyr849) EphA7 (Tyr608) EphA7 (Tyr614)
EphA7 (Tyr791) EphB1 (Tyr575) EphB1 (Tyr582) EphB1 (Tyr594)
EphB1 (Tyr600) EphB1 (Tyr634) EphB1 (Tyr778) EphB1 (Tyr798)
EphB2 iso2 (Tyr596) EphB2 iso2 (Tyr602) EphB2 iso2 (Tyr780) EphB2 (Tyr175)
EphB2 (Tyr181) EphB2 (Tyr194) EphB2 (Tyr577) EphB2 (Tyr584)
EphB2 (Tyr585) EphB2 (Tyr592) EphB2 (Tyr596) EphB2 (Tyr602)
EphB2 (Tyr604) EphB2 (Tyr610) EphB2 (Tyr780) EphB2 (Tyr788)
EphB2 (Tyr912) EphB3 (Tyr593) EphB3 (Tyr595) EphB3 (Tyr600)
EphB3 (Tyr603) EphB3 (Tyr608) EphB3 (Tyr609) EphB3 (Tyr614)
EphB3 (Tyr754) EphB3 (Tyr787) EphB3 (Tyr792) EphB3 (Tyr812)
EphB3 (Tyr919) EphB3 (Tyr924) EphB4 (Tyr574) EphB4 (Tyr581)
EphB4 (Tyr590) EphB4 (Tyr596) EphB4 (Tyr614) EphB4 (Tyr774)
EphB4 (Tyr906) EphB4 (Tyr987) EphB6 (Tyr628) EphB6 (Tyr635)
EphB6 (Tyr637) EphB6 (Tyr638) EphB6 (Tyr644) EphB6 (Tyr645)
EphB6 (Tyr651) FAK iso2 (Tyr216) FAK iso2 (Tyr226) FAK iso2 (Tyr418)
FAK iso2 (Tyr424) FAK iso2 (Tyr425) FAK iso3 (Tyr397) FAK iso3 (Tyr407)
FAK iso3 (Tyr570) FAK iso3 (Tyr576) FAK iso3 (Tyr577) FAK iso3 (Tyr861)
FAK (Tyr397) FAK (Tyr407) FAK (Tyr441) FAK (Tyr570)
FAK (Tyr576) FAK (Tyr577) FAK (Tyr608) FAK (Tyr614)
FAK (Tyr615) FAK (Tyr861) FAK (Tyr899) FAK (Tyr925)
FAK (Tyr936) Fer (Tyr402) Fer (Tyr714) Fer (Tyr715)
Fes (Tyr156) Fes (Tyr713) FGFR1 (Tyr154) FGFR1 (Tyr583)
FGFR1 (Tyr585) FGFR1 (Tyr653) FGFR1 (Tyr654) FGFR1 (Tyr730)
FGFR2 (Tyr466) FGFR2 (Tyr586) FGFR2 (Tyr588) FGFR2 (Tyr656)
FGFR2 (Tyr657) FGFR2 (Tyr805) FGFR2 (Tyr812) FGFR3 (Tyr577)
FGFR3 (Tyr647) FGFR3 (Tyr648) FGFR4 iso3 (Tyr874) FGFR4 iso3 (Tyr875)
FGFR4 (Tyr642) FGFR4 (Tyr643) Fgr (Tyr180) Fgr (Tyr208)
Fgr (Tyr209) Fgr (Tyr28) Fgr (Tyr34) Fgr (Tyr412)
Fgr (Tyr523) FLT3 (Tyr589) FLT3 (Tyr726) FLT3 (Tyr842)
FLT3 (Tyr969) FRK (Tyr104) FRK (Tyr132) FRK (Tyr221)
FRK (Tyr317) FRK (Tyr368) FRK (Tyr387) FRK (Tyr46)
FRK (Tyr497) FRK (Tyr504) FRK (Tyr53) FRK (Tyr99)
Fyn iso2 (Tyr213) Fyn iso2 (Tyr214) Fyn iso2 (Tyr417) Fyn (Tyr185)
Fyn (Tyr213) Fyn (Tyr214) Fyn (Tyr28) Fyn (Tyr339)
Fyn (Tyr420) Fyn (Tyr440) Fyn (Tyr531) Hck (Tyr207)
Hck (Tyr209) Hck (Tyr330) Hck (Tyr409) Hck (Tyr411)
Hck (Tyr51) Hck (Tyr520) Hck (Tyr522) HER2 (Tyr1005)
HER2 (Tyr1127) HER2 (Tyr1139) HER2 (Tyr1248) HER2 (Tyr735)
HER2 (Tyr877) HER2 (Tyr878) HER3 (Tyr1054) HER3 (Tyr1156)
HER3 (Tyr1159) HER3 (Tyr1197) HER3 (Tyr1199) HER3 (Tyr1262)
HER3 (Tyr1276) HER3 (Tyr1286) HER3 (Tyr1289) HER3 (Tyr1307)
HER3 (Tyr1325) HER3 (Tyr1328) HER4 (Tyr1056) HER4 (Tyr1128)
HER4 (Tyr1134) HER4 (Tyr1268) HER4 (Tyr1284) HER4 (Tyr733)
IGF1R (Tyr1161) IGF1R (Tyr1163) IGF1R (Tyr1165) IGF1R (Tyr1166)
IGF1R (Tyr1167) IGF1R (Tyr1168) IGF1R (Tyr1346) IGF1R (Tyr1352)
IGF1R (Tyr577) IGF1R (Tyr580) InsR iso2 (Tyr1173) InsR iso2 (Tyr1177)
InsR iso2 (Tyr1178) InsR iso2 (Tyr1343) InsR iso2 (Tyr1349) InsR (Tyr1149)
InsR (Tyr1175) InsR (Tyr1179) InsR (Tyr1180) InsR (Tyr1185)
InsR (Tyr1189) InsR (Tyr1190) InsR (Tyr1345) InsR (Tyr1351)
InsR (Tyr1355) InsR (Tyr1361) ITK (Tyr146) ITK (Tyr180)
ITK (Tyr198) ITK (Tyr273) ITK (Tyr40) ITK (Tyr512)
JAK1 (Tyr1033) JAK1 (Tyr1034) JAK1 (Tyr1035) JAK1 (Tyr220)
JAK2 (Tyr1007) JAK2 (Tyr1008) JAK2 (Tyr570) JAK2 (Tyr790)
JAK2 (Tyr813) JAK2 (Tyr931) JAK2 (Tyr940) JAK2 (Tyr956)
JAK2 (Tyr966) JAK3 (Tyr785) Kit (Tyr578) Kit (Tyr703)
Kit (Tyr721) Kit (Tyr730) Kit (Tyr936) Lck (Tyr192)
Lck (Tyr394) Lck (Tyr505) Lmr2 (Tyr1100) Lmr2 (Tyr1448)
Lmr2 (Tyr1468) Lmr3 (Tyr156) LTK (Tyr672) LTK (Tyr676)
LTK (Tyr677) Lyn iso2 (Tyr172) Lyn iso2 (Tyr173) Lyn iso2 (Tyr376)
Lyn iso2 (Tyr487) Lyn (Tyr117) Lyn (Tyr193) Lyn (Tyr194)
Lyn (Tyr265) Lyn (Tyr266) Lyn (Tyr306) Lyn (Tyr316)
Lyn (Tyr32) Lyn (Tyr397) Lyn (Tyr460) Lyn (Tyr473)
Lyn (Tyr501) Lyn (Tyr508) Mer (Tyr549) Mer (Tyr744)
Mer (Tyr748) Mer (Tyr749) Mer (Tyr753) Mer (Tyr754)
Mer (Tyr929) Met (Tyr1003) Met (Tyr1093) Met (Tyr1228)
Met (Tyr1230) Met (Tyr1232) Met (Tyr1233) Met (Tyr1234)
Met (Tyr1235) Met (Tyr1349) Met (Tyr1356) Met (Tyr1365)
NPM-ALK (Tyr138) NPM-ALK (Tyr152) NPM-ALK (Tyr156) NPM-ALK (Tyr191)
NPM-ALK (Tyr338) NPM-ALK (Tyr567) NPM-ALK (Tyr644) NPM-ALK (Tyr646)
NPM-ALK (Tyr664) PDGFRa (Tyr1018) PDGFRa (Tyr572) PDGFRa (Tyr574)
PDGFRa (Tyr613) PDGFRa (Tyr731) PDGFRa (Tyr742) PDGFRa (Tyr754)
PDGFRa (Tyr762) PDGFRa (Tyr768) PDGFRa (Tyr849) PDGFRa (Tyr944)
PDGFRa (Tyr958) PDGFRa (Tyr962) PDGFRa (Tyr988) PDGFRb (Tyr739)
PDGFRb (Tyr771) PDGFRb (Tyr778) PIK3C2A (Tyr73) PIK3C2B (Tyr1056)
PIK3C2B (Tyr127) PIK3C2B (Tyr1541) PIK3C2B (Tyr228) PIK3C2B (Tyr68)
PIK3C2G (Tyr1437) PIK3CA (Tyr317) PIK3CA (Tyr508) PIK3CB (Tyr246)
PIK3CB (Tyr425) PIK3CB (Tyr503) PIK3CB (Tyr504) PIK3CB (Tyr505)
PIK3CB (Tyr772) PIK3CB (Tyr956) PIK3CB (Tyr962) PIK3CD (Tyr484)
PIK3CD (Tyr485) PIK3CD (Tyr524) PIK3CD (Tyr935) PIK3CD (Tyr936)
PIK3CG (Tyr757) PIK3R1 (Tyr368) PIK3R1 (Tyr452) PIK3R1 (Tyr463)
PIK3R1 (Tyr467) PIK3R1 (Tyr470) PIK3R1 (Tyr508) PIK3R1 (Tyr528)
PIK3R1 (Tyr556) PIK3R1 (Tyr580) PIK3R1 (Tyr607) PIK3R2 (Tyr365)
PIK3R2 (Tyr443) PIK3R2 (Tyr449) PIK3R2 (Tyr453) PIK3R2 (Tyr458)
PIK3R2 (Tyr461) PIK3R2 (Tyr464) PIK3R2 (Tyr467) PIK3R2 (Tyr505)
PIK3R2 (Tyr599) PIK3R2 (Tyr605) PIK3R3 (Tyr195) PIK3R3 (Tyr199)
PIK3R3 (Tyr202) PIK3R3 (Tyr341) PIK4CA iso3 (Tyr1059) PIK4CA iso3 (Tyr1182)
PIK4CA iso3 (Tyr556) PIK4CA iso3 (Tyr719) PIK4CA (Tyr1096) PIK4CA (Tyr1745)
PIK4CA (Tyr2032) PIK4CA (Tyr470) PIK4CA (Tyr633) PIK4CA (Tyr973)
PIP5K1A iso2 (Tyr129) PIP5K1A iso2 (Tyr333) PIP5K1A iso2 (Tyr347) PIP5K1A (Tyr142)
PIP5K1A (Tyr346) PIP5K1A (Tyr360) PIP5K1A (Tyr483) PIP5K2A (Tyr246)
PIP5K2A (Tyr93) PIP5K2B (Tyr167) PIP5K2B (Tyr197) PIP5K2B (Tyr98)
PIP5KG (Tyr136) PIP5K (Tyr154) PIP5K (Tyr1772) PIP5K (Tyr1773)
PIP5K (Tyr324) Pyk2 iso2 (Tyr579) Pyk2 iso2 (Tyr580) Pyk2 iso2 (Tyr777)
Pyk2 (Tyr402) Pyk2 (Tyr579) Pyk2 (Tyr580) Pyk2 (Tyr683)
Pyk2 (Tyr699) Pyk2 (Tyr722) Pyk2 (Tyr819) Pyk2 (Tyr849)
Ret (Tyr1062) Ret (Tyr1096) Ret (Tyr687) Ret (Tyr900)
Ret (Tyr905) Ron (Tyr1238) Ron (Tyr1239) Ron (Tyr1353)
Ron (Tyr1360) ROR1 (Tyr160) ROR1 (Tyr173) ROR1 (Tyr786)
ROR1 (Tyr789) ROR1 (Tyr828) ROR1 (Tyr836) ROR2 (Tyr666)
ROR2 (Tyr873) ROS (Tyr1535) ROS (Tyr1923) ROS (Tyr2110)
ROS (Tyr2114) ROS (Tyr2115) ROS (Tyr2274) ROS (Tyr2323)
ROS (Tyr2334) ROS (Tyr2342) Src (Tyr187) Src (Tyr216)
Src (Tyr419) Src (Tyr424) Src (Tyr439) Src (Tyr444)
Src (Tyr530) Src (Tyr535) Syk (Tyr203) Syk (Tyr244)
Syk (Tyr296) Syk (Tyr317) Syk (Tyr323) Syk (Tyr342)
Syk (Tyr346) Syk (Tyr348) Syk (Tyr352) Syk (Tyr47)
Syk (Tyr525) Syk (Tyr526) Syk (Tyr568) Syk (Tyr630)
Syk (Tyr631) Syk (Tyr74) TEC (Tyr228) TEC (Tyr233)
TEC (Tyr518) TIE2 (Tyr897) Tnk1 (Tyr661) TrkA iso2 (Tyr670)
TrkA (Tyr676) TrkA (Tyr680) TrkA (Tyr681) TrkA (Tyr791)
TrkC iso2 (Tyr516) TrkC iso2 (Tyr597) TrkC iso2 (Tyr604) TrkC (Tyr516)
TTK (Tyr374) TTK (Tyr462) TTK (Tyr833) TTK (Tyr836)
Tyk2 (Tyr1054) Tyk2 (Tyr1145) Tyk2 (Tyr291) Tyk2 (Tyr292)
Tyk2 (Tyr433) Tyk2 (Tyr827) Tyro3 (Tyr671) Tyro3 (Tyr675)
Tyro3 (Tyr681) Tyro3 (Tyr685) Tyro3 (Tyr686) Tyro3 (Tyr828)
VEGFR-1 (Tyr1048) VEGFR-1 (Tyr1053) VEGFR-1 (Tyr1213) VEGFR-1 (Tyr1242)
VEGFR-1 (Tyr383) VEGFR-1 (Tyr388) VEGFR-1 (Tyr794) VEGFR-2 (Tyr1054)
VEGFR-2 (Tyr1059) VEGFR-2 (Tyr1214) VEGFR-3 (Tyr1063) VEGFR-3 (Tyr1068)
Yes (Tyr141) Yes (Tyr146) Yes (Tyr159) Yes (Tyr194)
Yes (Tyr220) Yes (Tyr221) Yes (Tyr222) Yes (Tyr223)
Yes (Tyr32) Yes (Tyr343) Yes (Tyr345) Yes (Tyr424)
Yes (Tyr426) Yes (Tyr444) Yes (Tyr446) Yes (Tyr535)
Yes (Tyr537) ZAP70 (Tyr164) ZAP70 (Tyr178) ZAP70 (Tyr248)
ZAP70 (Tyr292) ZAP70 (Tyr315) ZAP70 (Tyr319) ZAP70 (Tyr46)
ZAP70 (Tyr474) ZAP70 (Tyr492) ZAP70 (Tyr493) ZAP70 (Tyr597)
ZAP70 (Tyr598) ZAP70 (Tyr69) ZAP70 (Tyr87)