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PTMScan® Direct Apoptosis / Autophagy Service allows access to perform targeted screening and quantification of a defined set of protein sites within the or related to the Apoptosis or Autophagy pathways that are critical for drug discovery, biomarker discovery, or diagnostic development. The table below illustrates the list of protein sites that can be monitored with PTMScan® Direct Apoptosis / Autophagy Service.

Altogether, the PTMScan® Direct Apoptosis / Autophagy service provides a robust method to qualitatively identify and quantitatively profile 175 unique sites of phosphorylation and caspase cleavage on 100 proteins.

PTMScan Direct Apoptosis or Autophagy Pathway Coverage.

PTMScan® Direct Apoptosis / Autophagy Service Sample Case Study Data

PTMScan® Direct Apoptosis / Autophagy Protein Sites

Apoptosis / Autophagy Protein Sites
Apoptosis / Autophagy Protein Sites
α-Tubulin Akt1 Akt1 (Ser473) Akt1 (Ser477)
Akt1 (Thr305) Akt1 (Thr308) Akt1 (Thr312) Akt1 (Thr479)
Akt1 (Tyr315) Akt1 (Tyr474) Akt2 (Ser302) Akt2 (Thr306)
Akt2 (Thr309) Akt2 (Thr313) Akt2 (Tyr316) Akt3 (Ser472)
Akt3 (Ser474) Akt3 (Ser476) Akt3 (Thr302) Akt3 (Thr305)
Akt3 (Thr309) Akt3 (Tyr473) ANXA5 API5
ARC ATG12 ATG12 (Ser41) ATG12 (Thr30)
ATG3 ATG4C ATG7 ATG9A
β-Actin BAD (Ser97) BAD (Ser99) Bak1
Bcl-11B Bcl-9L Bcl-9L (Thr1370) Bcl-xL
Bid BIRC6 Casp2 Casp3
Casp3 (Asp175) Casp3 (Ser176) Casp6 Casp6 (Asp179)
Casp7 Casp7 (Asp198) Casp7 (Ser199) Casp8 (Asp374)
Casp9 Casp9 (Asp315) Casp9 (Ser302) Casp9 (Ser307)
CCAR1 CCDC72 CIAPIN1 CLU
CYC1 CYCS DBC-1 DBC-1 (Ser124)
DDAH2 DNA-PK ERK1 (Thr198) ERK1 (Thr202)
ERK1 (Tyr204) ERK2 (Thr181) ERK2 (Thr185) ERK2 (Thr190)
ERK2 (Tyr187) Fas Fas (Asp269) FYCO1
G6PI GAPDH GRP94 GSK3A (Thr19)
H3 HELLS IκBα (Ser32) IκBα (Ser36)
IκBα (Tyr42) IκBε (Ser18) IκBε (Ser22) IκBε (Ser25)
IKKβ Jun (Ser58) Jun (Ser63) Jun (Ser73)
Jun (Thr62) JunD (Ser100) JunD (Ser90) LDH-A
MIF MMRP19 mTOR mTOR (Ser2478)
mTOR (Ser2481) mTOR (Thr2471) mTOR (Thr2473) mTOR (Thr2474)
Myc NF-κB p105 NF-κB p105 (Ser923) NF-κB p105 (Ser927)
NF-κB p105 (Ser932) NF-κB p65 NF-κB p65 (Asp512) NF-κB p65 (Ser536)
Nik (Thr764) Nudt2 p400 PAR-4 (Asp131)
PARP1 PDCD10 PDCD5 PDCD8
PDCL3 PHLDA1 PI4K2A (Thr76) PIK3C2A
PIK3C3 PIK3CA PIK3CA (Ser507) PIK3CA (Tyr508)
PIK3CB PIK3CD PIK4CA PIP5K2A
PKCA PKCA (Thr494) PKCA (Thr501) PKCB
PKCB (Thr497) PKCB (Thr500) PKCB (Thr504) PKCB (Tyr507)
PKCH PKCT (Thr275) PKD1 (Ser473) PKD1 (Ser738)
PKD2 (Ser706) PKD3 (Ser731) PRAS40 PRAS40 (Ser203)
PRAS40 (Thr266) RABGAP1 Raptor Raptor (Ser877)
Raptor (Ser886) Raptor (Thr883) Raptor (Thr889) Rictor
ROCK1 ROCK2 RUSC1 SH3GLB1
SH3GLB2 SHP-2 SHP-2 (Ser580) SHP-2 (Tyr584)
SOD1 STAG1 Survivin Survivin (Asp72)
TNF-R1 ULK1 (Ser556) ULK4 (Thr645) XIAP
ZNF768 (Ser17) ZNF768 (Ser18) ZNF768 (Ser23)