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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

THOC4/ALY Antibody recognizes endogenous levels of total THOC4/ALY protein.

Species predicted to react based on 100% sequence homology: Hamster, Xenopus, Zebrafish, Bovine, Dog, Guinea Pig, Horse

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala245 of human THOC4/ALY protein. Antibodies are purified by protein A and peptide affinity chromatography.

mRNA export is a process that is tightly coupled to mRNA splicing (1-4). Splicing and packaging of mRNAs in the form of an mRNA-protein complex (mRNP) leads to the recruitment of the mRNA export adaptor THOC4/ALY, via its interaction with the splicing factor UAP56, forming a large complex termed the transcription-export complex (TREX) (1,2,5). THOC4/ALY then directly interacts with NXF1/TAP, a part of the heterodimer that targets the mRNP to the nuclear pore complex, resulting in the shuttling of mRNP out of the nucleus and into the cytoplasm (1-3,6).

1.  Katahira, J. (2012) Biochim Biophys Acta 1819, 507-13.

2.  Reed, R. and Magni, K. (2001) Nat Cell Biol 3, E201-4.

3.  Masuda, S. et al. (2005) Genes Dev 19, 1512-7.

4.  Luo, M.L. et al. (2001) Nature 413, 644-7.

5.  Kang, Y. and Cullen, B.R. (1999) Genes Dev 13, 1126-39.

6.  Siddiqui, N. and Borden, K.L. (2012) Wiley Interdiscip Rev RNA 3, 13-25.

Entrez-Gene Id 10189
Swiss-Prot Acc. Q86V81

For Research Use Only. Not For Use In Diagnostic Procedures.
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