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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Filamin C Antibody recognizes endogenous levels of total filamin C protein.

Species predicted to react based on 100% sequence homology: Monkey

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human filamin C protein. Antibodies are purified by protein A and peptide affinity chromatography.

Filamins are a family of dimeric actin binding proteins that function as structural components of cell adhesion sites. They also serve as a scaffold for subcellular targeting of signaling molecules (1). The actin binding domain (α-actinin domain) located at the amino terminus is followed by as many as 24 tandem repeats of about 96 residues and the dimerization domain is located at the carboxy terminus. In addition to actin filaments, filamins associate with other structural and signaling molecules such as β-integrins, Rho/Rac/Cdc42, PKC and the insulin receptor, primarily through the carboxy-terminal dimerization domain (1-3). Filamin A, the most abundant, and filamin B are widely expressed isoforms, while filamin C is predominantly expressed in muscle (1). Filamin A is phosphorylated by PAK1 at Ser2152, which is required for PAK1-mediated actin cytoskeleton reorganization (4).

1.  Stossel, T.P. et al. (2001) Nat Rev Mol Cell Biol 2, 138-45.

2.  Tigges, U. et al. (2003) J Biol Chem 278, 23561-9.

3.  He, H.J. et al. (2003) J Biol Chem 278, 27096-104.

4.  Vadlamudi, R.K. et al. (2002) Nat Cell Biol 4, 681-90.

Entrez-Gene Id 2318
Swiss-Prot Acc. Q14315

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

Filamin C Antibody