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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

MORF4L1/MRG15 Antibody recognizes endogenous levels of total MORF4L1/MRG15 protein. This antibody does not cross-react with MORF4L2/MRGX.

Species predicted to react based on 100% sequence homology: Hamster, Bovine, Dog, Guinea Pig, Horse

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala237 of human MORF4L1/MRG15 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Mortality factor 4-like protein 1 (MORF4L1/MRG15) is a chromo domain-containing protein that is part of several histone modifying complexes, including the Tip60 histone acetyltransferase (HAT) complex, histone deacetylase (HDAC) complexes, and the JARID1A and JARID1B histone demethylase complexes (1-6). MORF4L1/MRG15 recognizes di- or trimethylated Lys36 of histone H3 through its chromo domain. This interaction recruits and anchors MORF4L1/MRG15-associated chromatin modifying complexes to target genes for transcriptional regulation (7,8). MORF4L1/MRG15 plays a role in DNA repair as part of the Tip60 HAT complex (9,10). MORF4L1/MRG15 regulates alternative splicing during co-transcriptional splicing of mRNA as a part of the JARID1A complex (11). MORF4L1/MRG15 recruitment of the JARID1B complex to embryonic stem cell renewal-associated genes is important for repression of cryptic transcription and maintenance of proper transcriptional elongation (6).

1.  Pardo, P.S. et al. (2002) J Biol Chem 277, 50860-6.

2.  Yochum, G.S. and Ayer, D.E. (2002) Mol Cell Biol 22, 7868-76.

3.  Cai, Y. et al. (2003) J Biol Chem 278, 42733-6.

4.  Doyon, Y. et al. (2004) Mol Cell Biol 24, 1884-96.

5.  Hayakawa, T. et al. (2007) Genes Cells 12, 811-26.

6.  Xie, L. et al. (2011) EMBO J 30, 1473-84.

7.  Zhang, P. et al. (2006) Nucleic Acids Res 34, 6621-8.

8.  Joshi, A.A. and Struhl, K. (2005) Mol Cell 20, 971-8.

9.  Murr, R. et al. (2006) Nat Cell Biol 8, 91-9.

10.  Garcia, S.N. et al. (2007) FEBS Lett 581, 5275-81.

11.  Luco, R.F. et al. (2010) Science 327, 996-1000.

Entrez-Gene Id 10933
Swiss-Prot Acc. Q9UBU8

For Research Use Only. Not For Use In Diagnostic Procedures.
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