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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

CYP3A4 Antibody recognizes endogenous levels of total CYP3A4 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CYP3A4 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Cytochrome P450, subfamily 3A, polypeptide 4 (CYP3A4) is a mono-oxygenase enzyme (1) found in the endoplasmic reticulum membrane of liver and prostate microsomes. It is an important enzyme in drug metabolism; it catalyzes phase I oxidation reactions in approximately 50% of drugs in the modern market, as well as steroids, fatty acids, and some carcinogens (2). It is also involved in steroid and cholesterol synthesis (3,4). Expression of CYP3A4 can be induced by glucocorticoids, carcinogens, pesticides, and drugs, which can lead to drug interactions and toxicity (5).

1.  Gupta, R.P. et al. (2004) J Bone Miner Res 19, 680-8.

2.  Lynch, T. and Price, A. (2007) Am Fam Physician 76, 391-6.

3.  Pikuleva, I.A. (2006) Pharmacol Ther 112, 761-73.

4.  Tompkins, L.M. and Wallace, A.D. (2007) J Biochem Mol Toxicol 21, 176-81.

5.  Thummel, K.E. and Wilkinson, G.R. (1998) Annu Rev Pharmacol Toxicol 38, 389-430.

Entrez-Gene Id 1576
Swiss-Prot Acc. P08684

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

CYP3A4 Antibody