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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

EDC3 Antibody recognizes endogenous levels of total EDC3 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly322 of human EDC3 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Enhancer of mRNA decapping 3 (EDC3) was originally identified from Saccharomyces cerevisiae as a protein essential to mRNA decapping prior to 5’-3’ mRNA degradation (1). In human cells, EDC3 is found within cytoplasmic processing (P) bodies as part of complexes that include DCP1, DCP2, EDC4/Ge-1, and DDX6/RCK (2). EDC3 and DCP2 interact with TTP, an activator of AU-rich-element (ARE)-mediated decay pathway, to promote decapping and degradation of ARE mRNA (2). In addition, research studies indicate that EDC3 may play a role in the premature termination of RNA polymerase II transcription (3).

1.  Kshirsagar, M. and Parker, R. (2004) Genetics 166, 729-39.

2.  Fenger-Grøn, M. et al. (2005) Mol Cell 20, 905-15.

3.  Brannan, K. et al. (2012) Mol Cell 46, 311-24.

Entrez-Gene Id 80153
Swiss-Prot Acc. Q96F86

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

EDC3 Antibody