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Pdx1 Antibody #2437
This product is discontinued
Gallery: Pdx1 Antibody #2437
Pdx1 Antibody detects endogenous levels of total Pdx1 protein.Species predicted to react based on 100% sequence homology: Human
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to human Pdx1. Antibodies are purified by protein A and peptide affinity chromatography.
The pancreatic duodenal homeobox gene-1 (Pdx1) is a transcription factor that contributes to pancreas development, pancreatic β-cell differentiation, and mature β-cell function (1,2). It plays an essential role in the commitment of endoderm to a pancreatic and later β-cell phenotype (2,3). In the mature pancreas, Pdx1 expression is more restricted to the pancreatic β-cells (3), where it promotes the expression of genes important for β-cell functions such as insulin, glucokinase, and Glut2 (4-6). Mutations of the corresponding Pdx1 gene may be associated with diabetes and cases of pancreatic insufficiency (7).
For Research Use Only. Not For Use In Diagnostic Procedures. Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.