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Pdx1 Antibody #2437
This product is discontinued
Gallery: Pdx1 Antibody #2437
Pdx1 Antibody detects endogenous levels of total Pdx1 protein.Species predicted to react based on 100% sequence homology: Human
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to human Pdx1. Antibodies are purified by protein A and peptide affinity chromatography.
The pancreatic duodenal homeobox gene-1 (Pdx1) is a transcription factor that contributes to pancreas development, pancreatic β-cell differentiation, and mature β-cell function (1,2). It plays an essential role in the commitment of endoderm to a pancreatic and later β-cell phenotype (2,3). In the mature pancreas, Pdx1 expression is more restricted to the pancreatic β-cells (3), where it promotes the expression of genes important for β-cell functions such as insulin, glucokinase, and Glut2 (4-6). Mutations of the corresponding Pdx1 gene may be associated with diabetes and cases of pancreatic insufficiency (7).
For Research Use Only. Not For Use In Diagnostic Procedures. Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.