Upstream / Downstream


Explore pathways related to this product.

Antibody Guarantee

CST Antibody Performance Guarantee



Find answers on our FAQs page.


Visit PhosphoSitePlus®

PTM information and tools available.


120 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Histone Deacetylase 7 (HDAC7) Antibody detects endogenous levels of total HDAC7 protein. The antibody does not cross-react with other HDAC proteins.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the amino-terminal sequence of human HDAC7. Antibodies are purified by protein A and peptide affinity chromatography.

Acetylation of the histone tail causes chromatin to adopt an "open" conformation, allowing increased accessibility of transcription factors to DNA. The identification of histone acetyltransferases (HATs) and their large multiprotein complexes has yielded important insights into how these enzymes regulate transcription (1,2). HAT complexes interact with sequence-specific activator proteins to target specific genes. In addition to histones, HATs can acetylate nonhistone proteins, suggesting multiple roles for these enzymes (3). In contrast, histone deacetylation promotes a "closed" chromatin conformation and typically leads to repression of gene activity (4). Mammalian histone deacetylases can be divided into three classes on the basis of their similarity to various yeast deacetylases (5). Class I proteins (HDACs 1, 2, 3, and 8) are related to the yeast Rpd3-like proteins, those in class II (HDACs 4, 5, 6, 7, 9, and 10) are related to yeast Hda1-like proteins, and class III proteins are related to the yeast protein Sir2. Inhibitors of HDAC activity are now being explored as potential therapeutic cancer agents (6,7).

1.  Marmorstein, R. (2001) Cell Mol Life Sci 58, 693-703.

2.  Gregory, P.D. et al. (2001) Exp Cell Res 265, 195-202.

3.  Liu, Y. et al. (2000) Mol Cell Biol 20, 5540-53.

4.  Cress, W.D. and Seto, E. (2000) J Cell Physiol 184, 1-16.

5.  Gray, S.G. and Ekström, T.J. (2001) Exp Cell Res 262, 75-83.

6.  Thiagalingam, S. et al. (2003) Ann. N.Y. Acad. Sci. 983, 84-100.

7.  Vigushin, D.M. and Coombes, R.C. (2004) Curr Cancer Drug Targets 4, 205-18.

Entrez-Gene Id 51564
Swiss-Prot Acc. Q8WUI4

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

Histone Deacetylase 7 (HDAC7) Antibody