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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Keratin 7 Antibody detects endogenous levels of keratin 7 protein.

Species predicted to react based on 100% sequence homology: Monkey

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acids at the amino-terminus of human keratin 7. Polyclonal antibodies are purified by Protein A and peptide affinity chromatography.

Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) assemble to form filaments (1,2). Keratin isoforms demonstrate tissue- and differentiation-specific profiles that make them useful as research biomarkers (1). Research studies have shown that mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases (3-6).

Keratin 7 and Keratin 19 are present in hepatic and pancreatic progenitor/stem cells (7,8).

1.  Moll, R. et al. (1982) Cell 31, 11-24.

2.  Ramaekers, F.C. and Bosman, F.T. (2004) J Pathol 204, 351-4.

3.  Chang, L. and Goldman, R.D. (2004) Nat Rev Mol Cell Biol 5, 601-13.

4.  Lane, E.B. and McLean, W.H. (2004) J Pathol 204, 355-66.

5.  Zatloukal, K. et al. (2004) J Pathol 204, 367-76.

6.  Owens, D.W. and Lane, E.B. (2004) J Pathol 204, 377-85.

7.  Iyer, A. et al. (2008) Hum Pathol 39, 1370-7.

8.  Meier, K. et al. (2009) Ann Anat 191, 70-82.

Entrez-Gene Id 3855
Swiss-Prot Acc. P08729

For Research Use Only. Not For Use In Diagnostic Procedures.
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Keratin 7 Antibody