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15 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

KCNE1 Antibody detects endogenous levels of total KCNE1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp76 of human KCNE1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Voltage-gated potassium channels play a variety of important roles in human health and disease (1,2). KCNE1, also known as MinK, belongs to a family of small transmembrane proteins (KCNE1, 2, 3, 4, and KCNE1L) that modulate the activity of several voltage-gated K+ channels (3-5). KCNE1 functions as the modulatory β-subunit of the pore-forming α-subunit KCNQ1, and alters several biophysical properties of KCNQ1 channels (6,7). Research studies have shown that several inherited mutations in KCNE1 result in long QT syndrome (8-10) and deafness (11).

1.  Jespersen, T. et al. (2005) Physiology (Bethesda) 20, 408-16.

2.  Robbins, J. (2001) Pharmacol Ther 90, 1-19.

3.  Takumi, T. et al. (1988) Science 242, 1042-5.

4.  Abbott, G.W. and Goldstein, S.A. (2001) Mol Interv 1, 95-107.

5.  McCrossan, Z.A. and Abbott, G.W. (2004) Neuropharmacology 47, 787-821.

6.  Barhanin, J. et al. (1996) Nature 384, 78-80.

7.  Sanguinetti, M.C. et al. (1996) Nature 384, 80-3.

8.  Splawski, I. et al. (1997) Nat Genet 17, 338-40.

9.  Abbott, G.W. and Goldstein, S.A. (2002) FASEB J 16, 390-400.

10.  Tian, C. et al. (2007) Biochemistry 46, 11459-72.

11.  Peters, T.A. et al. (2004) Pediatr Nephrol 19, 1194-201.

Entrez-Gene Id 3753
Swiss-Prot Acc. P15382

For Research Use Only. Not For Use In Diagnostic Procedures.
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