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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

RIP2 Antibody detects endogenous levels of total RIP2 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human RIP2. Antibodies are purified by protein A and peptide affinity chromatography.

Receptor Interacting Protein 2 (RIP2) is a serine/threonine kinase with a carboxy-terminal caspase activation and recruitment domain (CARD). Association of RIP2 with the tumor necrosis factor receptor (TNFR) causes activation of NF-κB and induction of apoptosis (1-3). Expression of RIP2 is induced in macrophages upon exposure to bacterial cell wall components, such as LPS. RIP2-deficient mouse models demonstrate that this kinase integrates and transduces signals for both the innate and adaptive immune system (4,5).

1.  Inohara, N. et al. (1998) J Biol Chem 273, 12296-300.

2.  McCarthy, J.V. et al. (1998) J Biol Chem 273, 16968-75.

3.  Thome, M. et al. (1998) Curr Biol 8, 885-8.

4.  Chin, A.I. et al. (2002) Nature 416, 190-4.

5.  Kobayashi, K. et al. (2002) Nature 416, 194-9.

Entrez-Gene Id 8767
Swiss-Prot Acc. O43353

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

RIP2 Antibody