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RIP2 Antibody #4982
This product is discontinued
Gallery: RIP2 Antibody #4982
RIP2 Antibody detects endogenous levels of total RIP2 protein.
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human RIP2. Antibodies are purified by protein A and peptide affinity chromatography.
Receptor Interacting Protein 2 (RIP2) is a serine/threonine kinase with a carboxy-terminal caspase activation and recruitment domain (CARD). Association of RIP2 with the tumor necrosis factor receptor (TNFR) causes activation of NF-κB and induction of apoptosis (1-3). Expression of RIP2 is induced in macrophages upon exposure to bacterial cell wall components, such as LPS. RIP2-deficient mouse models demonstrate that this kinase integrates and transduces signals for both the innate and adaptive immune system (4,5).
For Research Use Only. Not For Use In Diagnostic Procedures. Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.