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REACTIVITY SENSITIVITY MW (kDa) SOURCE
145, >300 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

mGluR1 Antibody detects endogenous levels of total mGluR1 protein.


Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu1105 of the α isoform of human mGluR1. Antibodies are purified by protein A and peptide affinity chromatography.

Metabotropic glutamate receptor 1 (mGluR1) is a G protein-coupled receptor (GPCR) for the neurotransmitter glutamate in the mammalian brain. Unlike ionotropic receptors, metabotropic receptors do not form an ion channel pore themselves but are indirectly linked to ion channels (1). Both mGluR1 and mGluR5 are coupled to phospholipase C and activate inositol phospholipid metabolism via G protein-mediated mechanisms. Upon phosphatidylinositol activation, the second messenger calcium is released and generates a calcium-activated chloride current. Metabotropic glutamate receptors other than mGluR1 and mGluR5 inhibit adenylate cyclase (1-3). mGluR1 does not share sequence homology with conventional GPCRs (1). mGluR1 forms a homodimer and is linked to synaptic plasticity, as well as long-term potentiation and long-term depression. Furthermore, mGluR1 is a potential therapeutic target for various psychiatric and neurological diseases, including schizophrenia, epilepsy, and Parkinson and Alzheimer diseases (4-6).


1.  Pin, J.P. et al. (1994) EMBO J 13, 342-8.

2.  Sugiyama, H. et al. (1987) Nature 325, 531-3.

3.  Hermans, E. and Challiss, R.A. (2001) Biochem J 359, 465-84.

4.  Niswender, C.M. et al. (2005) Curr Top Med Chem 5, 847-57.

5.  Pellicciari, R. and Costantino, G. (1999) Curr Opin Chem Biol 3, 433-40.

6.  Olive, M.F. (2009) Curr Drug Abuse Rev 2, 83-989.


Entrez-Gene Id 2911
Swiss-Prot Acc. Q13255


For Research Use Only. Not For Use In Diagnostic Procedures.
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