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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

ETS-1 Antibody recognizes endogenous levels of total ETS-1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser179 of human ETS-1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

ETS-1 is a proto-oncoprotein that belongs to the E26 Transformation-specific Sequence (ETS) family of transcription factors that share a unique and highly conserved DNA binding domain (1). ETS-1 plays important roles in vascular development and angiogenesis (2), and vascular inflammation and remodeling (3). The target genes of ETS-1 include receptor tyrosine kinases, MMPs, and cell adhesion molecules (4-6). In addition, ETS-1 is involved in regulation of energy metabolism in cancer cells (7). ETS-1 activity is regulated by two different types of phosphorylation sites. While phosphorylation at a cluster of serine residues in the exon VII domain by CaMKII inhibits ETS-1 DNA binding activity (8), phosphorylation at its Thr38 site by Ras activates ETS-1 (9).

1.  Bartel, F.O. et al. (2000) Oncogene 19, 6443-54.

2.  Sato, Y. (2001) Cell Struct Funct 26, 19-24.

3.  Oettgen, P. (2006) Circ Res 99, 1159-66.

4.  Dube, A. et al. (1999) Circ Res 84, 1177-85.

5.  Lelièvre, E. et al. (2000) Oncogene 19, 2438-46.

6.  Ghosh, S. et al. (2012) J Biol Chem 287, 15001-15.

7.  Verschoor, M.L. et al. (2010) PLoS One 5, e13565.

8.  Pognonec, P. et al. (1988) EMBO J 7, 977-83.

9.  Yang, B.S. et al. (1996) Mol Cell Biol 16, 538-47.

Entrez-Gene Id 2113
Swiss-Prot Acc. P14921

For Research Use Only. Not For Use In Diagnostic Procedures.
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ETS-1 Antibody