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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

PGAM1 Antibody recognizes endogenous levels of total PGAM1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro128 of human PGAM1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Phosphoglycerate mutase (PGAM1) catalyzes the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis (1-5). Research studies have shown increased PGAM1 expression in cancer (1-4) and mental disease (5). Specifically, PGAM1 was shown to be phosphorylated at His11 by phosphoenolpyruvate (PEP) in PKM2-expressing cells, suggesting a possible regulatory role for PGAM1 in actively proliferating cells via an alternative glycolytic pathway (1).

1.  Jacobowitz, D.M. et al. (2008) Microvasc Res 76, 89-93.

2.  Ren, F. et al. (2010) Mol Cancer 9, 81.

3.  Vander Heiden, M.G. et al. (2010) Science 329, 1492-9.

4.  Evans, M.J. et al. (2005) Nat Biotechnol 23, 1303-7.

5.  Martins-de-Souza, D. et al. (2009) BMC Psychiatry 9, 17.

Entrez-Gene Id 5223
Swiss-Prot Acc. P18669

For Research Use Only. Not For Use In Diagnostic Procedures.
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