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83 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Gelsolin Antibody recognizes endogenous levels of total gelsolin protein.

Species predicted to react based on 100% sequence homology: Monkey

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val377 of human gelsolin protein. Antibodies are purified by protein A and peptide affinity chromatography.

Gelsolin (actin-depolymerizing factor, ADF, AGEL, Brevin) is an 83 kDa protein that shares structural and functional homology to villin and adseverin/scinderin (1,2). Gelsolin plays an important role in actin filament assembly by capping and severing actin proteins in a Ca2+-dependent manner (3,4). Gelsolin is important for cellular events (e.g., membrane ruffling, chemotaxis, ciliogenesis) that require cytoskeletal remodeling (3). Accordingly, cells from gelsolin knockout mice exhibit motility defects, including a failure to ruffle in response to growth factor stimulation (5,6). In humans, defects in gelsolin have been linked to amyloidosis type 5 (AMYL5), a hereditary disease characterized by cranial neuropathy, which appears to result from gelsolin amyloid deposition (7).

1.  Vitale, M.L. et al. (1991) J Cell Biol 113, 1057-67.

2.  Lueck, A. et al. (1998) J Cell Sci 111 ( Pt 24), 3633-43.

3.  Sun, H.Q. et al. (1999) J Biol Chem 274, 33179-82.

4.  Li, G.H. et al. (2010) Med Res Rev, 32, 999-1025.

5.  Azuma, T. et al. (1998) EMBO J 17, 1362-70.

6.  Lu, M. et al. (1997) J Cell Biol 138, 1279-87.

7.  Haltia, M. et al. (1990) Biochem Biophys Res Commun 167, 927-32.

Entrez-Gene Id 2934
Swiss-Prot Acc. P06396

For Research Use Only. Not For Use In Diagnostic Procedures.
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