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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Rhodopsin Antibody recognizes endogenous levels of total rhodopsin protein. This antibody may also detect rhodopsin protein at 55 kDa.

Species predicted to react based on 100% sequence homology: Hamster, Monkey

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro7 of human rhodopsin protein. Antibodies are purified by protein A and peptide affinity chromatography.

Rhodopsin is the photoreceptor in the retinal rods. It is activated by photons, transduces visual information through its cognate G protein, transducin, and is inactivated by arrestin binding (1). Using atomic-force microscopy, rhodopsin was found to be arranged into paracrystalline arrays of dimers in mouse disc membranes (2). Rhodopsin is considered to be the prototype of G protein-coupled receptors (GPCRs), and is the first GPCR for which a crystal structure was solved (3). Research studies have linked mutations in the gene encoding rhodopsin to retinitis pigmentosa (4,5), a disease characterized by retinal degeneration resulting in reduced peripheral vision and night blindness (6).

1.  Arshavsky, V.Y. and Burns, M.E. (2012) J Biol Chem 287, 1620-6.

2.  Fotiadis, D. et al. (2003) Nature 421, 127-8.

3.  Palczewski, K. et al. (2000) Science 289, 739-45.

4.  Rivolta, C. et al. (2002) Hum Mol Genet 11, 1219-27.

5.  Wilson, J.H. and Wensel, T.G. (2003) Mol Neurobiol 28, 149-58.

6.  Hartong, D.T. et al. (2006) Lancet 368, 1795-809.

Entrez-Gene Id 6010
Swiss-Prot Acc. P08100

For Research Use Only. Not For Use In Diagnostic Procedures.
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Rhodopsin Antibody