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REACTIVITY SENSITIVITY MW (kDa) SOURCE
160 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Kinectin 1 Antibody recognizes endogenous levels of total kinectin 1 protein.


Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human kinectin 1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Kinectin 1 (KTN1) is an endoplasmic reticulum (ER)-enriched integral membrane protein that may be involved in the formation of ER sheets (reviewed in 1). Kinectin 1 binds the microtubule motor protein kinesin and acts as a membrane anchor for kinesin-based organelle trafficking (2). The interaction of kinesin with kinectin 1 has been shown to affect ER-supported focal adhesion assembly (3). Kinectin 1 has also been implicated in translation elongation, as an anchor for the elongation factor complex to the ER (4,5). Research investigators have shown that kinectin 1 expression is altered in multiple human pathologies, including breast cancer (6), hepatocellular carcinoma (HCC) (7), Parkinson's disease (8), and the autoimmune syndrome Behçet's disease (BD) (9,10).


1.  Lin, S. et al. (2012) Int J Biochem Cell Biol 44, 1436-43.

2.  Kumar, J. et al. (1995) Science 267, 1834-7.

3.  Zhang, X. et al. (2010) J Cell Sci 123, 3901-12.

4.  Ong, L.L. et al. (2003) J Biol Chem 278, 32115-23.

5.  Ong, L.L. et al. (2006) J Biol Chem 281, 33621-34.

6.  Sutton, C.W. et al. (2010) J Proteome Res 9, 3891-902.

7.  Wang, H.C. et al. (2004) Biochem Cell Biol 82, 321-7.

8.  van Dijk, K.D. et al. (2012) Brain Pathol 22, 485-98.

9.  Lu, Y. et al. (2005) Arthritis Res Ther 7, R1133-9.

10.  Feng, X.G. et al. (2007) Clin Exp Rheumatol 25, S80-5.


Entrez-Gene Id 3895
Swiss-Prot Acc. Q86UP2


For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
Tween is a registered trademark of ICI Americas, Inc.

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Kinectin 1 Antibody