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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Aromatase Antibody recognizes endogenous levels of total aromatase protein. This antibody also cross-reacts with a 32 kDa protein of unknown origin in some cells.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human aromatase protein. Antibodies are purified by protein A and peptide affinity chromatography.

Aromatase is a member of the cytochrome P450 superfamily of enzymes, which are monooxygenases that catalyze reactions involved in drug metabolism and cholesterol and steroid synthesis (1,2). Aromatase is responsible for the conversion of testosterone into 17-β estradiol (2). Aromatase is mainly expressed in the brain (3), ovaries (4), and placenta (5). Aromatase plays an important role in development of the central nervous system during ontogenesis (6,7), gonadal development, and sex differentiation (8,9). Research studies have suggested that inhibition of aromatase may be an effective therapeutic strategy for postmenopausal breast cancers that are estrogen receptor positive (6,10). Mutations in the corresponding aromatase gene are associated with cases of aromatase excess syndrome (AEXS) and aromatase deficiency (AROD) disorders (11-14).

1.  Harada, N. (1988) Biochem Biophys Res Commun 156, 725-32.

2.  Chen, S.A. et al. (1988) DNA 7, 27-38.

3.  Hinshelwood, M.M. et al. (2000) Endocrinology 141, 2050-3.

4.  Pezzi, V. et al. (2003) J Steroid Biochem Mol Biol 87, 181-9.

5.  Peruffo, A. et al. (2011) Gen Comp Endocrinol 172, 211-7.

6.  Montelli, S. et al. (2012) Brain Res 1475, 11-8.

7.  Kuntz, S. et al. (2003) Cytogenet Genome Res 101, 283-8.

8.  Ramsey, M. et al. (2007) Differentiation 75, 978-91.

9.  Hu, Q. et al. (2012) J Med Chem 55, 7080-9.

10.  Gilani, R.A. et al. (2012) Breast Cancer Res Treat 135, 681-92.

11.  Ito, Y. et al. (1993) Proc Natl Acad Sci U S A 90, 11673-7.

12.  Morishima, A. et al. (1995) J Clin Endocrinol Metab 80, 3689-98.

13.  Carani, C. et al. (1997) N Engl J Med 337, 91-5.

14.  Fukami, M. et al. (2012) Int J Endocrinol 2012, 584807.

Entrez-Gene Id 1588
Swiss-Prot Acc. P11511

For Research Use Only. Not For Use In Diagnostic Procedures.
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Aromatase Antibody