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REACTIVITY SENSITIVITY MW (kDa) Isotype
H M R Endogenous 22 Rabbit IgG

Western blot analysis of extracts from human and rat brain using CEND1 (D6A6) Rabbit mAb.

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Product Usage Information

Application Dilutions
Western Blotting 1:1000
Immunoprecipitation 1:100
Immunofluorescence 1:400

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

CEND1 (D6A6) Rabbit mAb recognizes endogenous levels of total CEND1 protein.


Species Reactivity: Human, Mouse, Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CEND1 protein.

The progression of progenitor cells towards neuronal differentiation is regulated by cell cycle control and the transition from proliferative to neurogenic cell divisions. Cell cycle exit and neuronal differentiation 1 (CEND1) is a neuronal protein widely expressed in the adult nervous system (1). It is implicated in the synchronization of cell cycle exit and differentiation of neuronal precursors in the developing nervous system, and its expression marks the exit of proliferative cells from the cell cycle (2,3). Levels of CEND1 expression in the subventricular zone of the adult nervous system are critical for cell cycle control and neuronal differentiation mechanisms during neonatal SVZ neurogenesis (4). It has recently been shown that neural progenitor cells (NPCs) that overexpress CEND1 display increased neuronal differentiation in a mouse model of brain injury, suggesting its potential use as a therapeutic intervention for neurodegenerative diseases and brain injury (5).


1.  Patsavoudi, E. et al. (1995) J Neurosci Res 40, 506-18.

2.  Politis, P.K. et al. (2007) Proc Natl Acad Sci USA 104, 17861-6.

3.  Koutmani, Y. et al. (2004) Eur J Neurosci 20, 2509-23.

4.  Katsimpardi, L. et al. (2008) Stem Cells 26, 1796-807.

5.  Makri, G. et al. (2010) Stem Cells 28, 127-39.


Entrez-Gene Id 51286
Swiss-Prot Acc. Q8N111


For Research Use Only. Not For Use In Diagnostic Procedures.
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