Upstream / Downstream


Explore pathways related to this product.

Antibody Guarantee

CST Antibody Performance Guarantee


To get local purchase information on this product, click here


Find answers on our FAQs page.


Visit PhosphoSitePlus®

PTM information and tools available.


15 Rabbit 

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

KCNE1 (D2D5) Rabbit mAb recognizes endogenous levels of total KCNE1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn75 of human KCNE1 protein.

Voltage-gated potassium channels play a variety of important roles in human health and disease (1,2). KCNE1, also known as MinK, belongs to a family of small transmembrane proteins (KCNE1, 2, 3, 4, and KCNE1L) that modulate the activity of several voltage-gated K+ channels (3-5). KCNE1 functions as the modulatory β-subunit of the pore-forming α-subunit KCNQ1, and alters several biophysical properties of KCNQ1 channels (6,7). Research studies have shown that several inherited mutations in KCNE1 result in long QT syndrome (8-10) and deafness (11).

1.  Jespersen, T. et al. (2005) Physiology (Bethesda) 20, 408-16.

2.  Robbins, J. (2001) Pharmacol Ther 90, 1-19.

3.  Takumi, T. et al. (1988) Science 242, 1042-5.

4.  Abbott, G.W. and Goldstein, S.A. (2001) Mol Interv 1, 95-107.

5.  McCrossan, Z.A. and Abbott, G.W. (2004) Neuropharmacology 47, 787-821.

6.  Barhanin, J. et al. (1996) Nature 384, 78-80.

7.  Sanguinetti, M.C. et al. (1996) Nature 384, 80-3.

8.  Splawski, I. et al. (1997) Nat Genet 17, 338-40.

9.  Abbott, G.W. and Goldstein, S.A. (2002) FASEB J 16, 390-400.

10.  Tian, C. et al. (2007) Biochemistry 46, 11459-72.

11.  Peters, T.A. et al. (2004) Pediatr Nephrol 19, 1194-201.

Entrez-Gene Id 3753
Swiss-Prot Acc. P15382

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.