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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Langerin Antibody recognizes endogenous levels of total langerin protein.

Species predicted to react based on 100% sequence homology: Mouse

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala81 of mouse langerin protein. Antibodies are purified by protein A and peptide affinity chromatography.

Langerin (CD207) is a C-type lectin receptor whose expression is restricted mainly to dendritic cells in the skin including Langerhans cells in the epidermis and langerin+/CD103+ dermal dendritic cells (1-4). Langerin is found on the cell surface and within rod-shaped organelles called Birbeck granules, and its expression is required for the formation of Birbeck granules (1,5). Langerin recognizes carbohydrate motifs on the surface of pathogens, resulting in endocytosis of the pathogen into Birbeck granules, degradation of the pathogen, and antigen presentation to T cells (6-8).

1.  Valladeau, J. et al. (2000) Immunity 12, 71-81.

2.  Poulin, L.F. et al. (2007) J Exp Med 204, 3119-31.

3.  Ginhoux, F. et al. (2007) J Exp Med 204, 3133-46.

4.  Bursch, L.S. et al. (2007) J Exp Med 204, 3147-56.

5.  Kissenpfennig, A. et al. (2005) Mol Cell Biol 25, 88-99.

6.  Stambach, N.S. and Taylor, M.E. (2003) Glycobiology 13, 401-10.

7.  Idoyaga, J. et al. (2008) J Immunol 180, 3647-50.

8.  Igyártó, B.Z. et al. (2011) Immunity 35, 260-72.

Entrez-Gene Id 50489
Swiss-Prot Acc. Q9UJ71

For Research Use Only. Not For Use In Diagnostic Procedures.
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Langerin Antibody