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REACTIVITY SENSITIVITY MW (kDa) SOURCE
22 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

CEND1 Antibody recognizes endogenous levels of total CEND1 protein.


Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CEND1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

The progression of progenitor cells towards neuronal differentiation is regulated by cell cycle control and the transition from proliferative to neurogenic cell divisions. Cell cycle exit and neuronal differentiation 1 (CEND1) is a neuronal protein widely expressed in the adult nervous system (1). It is implicated in the synchronization of cell cycle exit and differentiation of neuronal precursors in the developing nervous system, and its expression marks the exit of proliferative cells from the cell cycle (2,3). Levels of CEND1 expression in the subventricular zone of the adult nervous system are critical for cell cycle control and neuronal differentiation mechanisms during neonatal SVZ neurogenesis (4). It has recently been shown that neural progenitor cells (NPCs) that overexpress CEND1 display increased neuronal differentiation in a mouse model of brain injury, suggesting its potential use as a therapeutic intervention for neurodegenerative diseases and brain injury (5).


1.  Patsavoudi, E. et al. (1995) J Neurosci Res 40, 506-18.

2.  Politis, P.K. et al. (2007) Proc Natl Acad Sci USA 104, 17861-6.

3.  Koutmani, Y. et al. (2004) Eur J Neurosci 20, 2509-23.

4.  Katsimpardi, L. et al. (2008) Stem Cells 26, 1796-807.

5.  Makri, G. et al. (2010) Stem Cells 28, 127-39.


Entrez-Gene Id 51286
Swiss-Prot Acc. Q8N111


For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
DRAQ5 is a registered trademark of Biostatus Limited.

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CEND1 Antibody