Product Pathways - Neuroscience
SSTR1 Antibody #11830
|11830S||100 µl (10 western blots)||---||In Stock||---|
|11830||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Species predicted to react based on 100% sequence homology: Human, Mouse, Monkey.
Specificity / Sensitivity
SSTR1 Antibody recognizes endogenous levels of total SSTR1 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val365 of human SSTR1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Western blot analysis of extracts from COS-7 cells, mock transfected (-) or transfected with a construct expressing human SSTR1 (hSSTR1; +), using SSTR1 Antibody. Multiple bands are thought to be GPCR dimers and/or oligomers (Rozenfeld, R. and Devi, L.A. (2010) Handbook of Cell Signaling, 2nd edition, 185-94). Smearing is thought to be due to the addition of N-linked glycosylations at specific NXS/T motifs (Dong, C. et al. (2007) Biochem Biophys Acta 1768, 853-70).
Somatostatin receptors are part of the super family of G protein-coupled receptors. Five genes encoding six different somatostatin receptor subtypes (SSTR1, SSTR2A, SSTR2B, SSTR3, SSTR4, and SSTR5) have been cloned (1). Somatostatin receptors are activated by somatostatin, a neuropeptide that acts as a neurotransmitter in the brain that regulates hormone secretion from endocrine tissues (2). Somatostatin receptors are found to be highly expressed on human neuroendocrine tumors (3).
mRNA expression data and immunohistochemical studies indicate high expression of SSTR1 in pituitary and gastroenteropancreatic tumor, renal, colorectal and breast cancer, meningioma, glioma neuroblastoma, and pheochromocytoma (3).
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