Product Pathways - Transcription Factors
NFI-C Antibody #11911
|11911S||100 µl (10 western blots)||---||In Stock||---|
|11911||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||55-65||Rabbit|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Specificity / Sensitivity
NFI-C Antibody recognizes endogenous levels of total NFI-C protein. This antibody also recognizes overexpressed NFI-B protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala263 of human NFI-C protein. Antibodies are purified by protein A and peptide affinity chromatography.
NFI-C belongs to the nuclear factor I (NFI) family of site-specific transcription factors that regulate viral DNA replication and expression of various genes (1,2). The NFI family is composed of four members in vertebrates: NFI-A, NFI-B, NFI-C, and NFI-X, all of which are critical in the development of multiple organ systems in mice and humans (3). NFI-C is expressed in various tissues and regulates TGF-β dependent tooth development and hair follicle cycling (3-5). Research studies have shown that NFI-C directly represses FoxF1 transcription and suppresses the motility and invasiveness of breast cancer cells (6).
- Gronostajski, R.M. (2000) Gene 249, 31-45.
- Liang, B. et al. (2012) J Virol 86, 3264-75.
- Steele-Perkins, G. et al. (2003) Mol Cell Biol 23, 1075-84.
- Lee, D.S. et al. (2009) J Biol Chem 284, 17293-303.
- Plasari, G. et al. (2010) J Biol Chem 285, 34115-25.
- Nilsson, J. et al. (2010) Cancer Res 70, 2020-9.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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