Product Pathways - Protein Translation
ATP2A1/SERCA1 (D54G12) Rabbit mAb #12293
|12293S||100 µl (10 western blots)||---||In Stock||---|
|12293||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse||Endogenous||100||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Species predicted to react based on 100% sequence homology: Rat.
Specificity / Sensitivity
ATP2A1/SERCA1 (D54G12) Rabbit mAb recognizes endogenous levels of total ATP2A1/SERCA1 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro995 of human ATP2A1/SERCA1 protein.
Sarcoplasmic and endoplasmic reticulum Ca2+ ATPases (SERCA) are members of a highly conserved family of Ca2+ pumps (1). SERCA pumps transport Ca2+ from the cytosol to the sarcoplasmic and endoplasmic reticulum lumen against a large concentration gradient (1). ATP2A1 (SERCA1) is a fast-twitch, skeletal muscle sarcoplasmic reticulum Ca2+ ATPase (2). Research studies have shown that mutations in the ATP2A1 gene cause an autosomal recessive muscle disorder known as Brody myopathy, which is characterized by muscle cramping and impaired muscle relaxation associated with exercise (1-3).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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