Product Pathways - Translational Control
hnRNP C1/C2 Antibody #12392
|12392S||100 µl (10 western blots)||---||In Stock||---|
|12392||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
hnRNP C1/C2 Antibody recognizes endogenous levels of total hnRNP C1/C2 protein. This antibody does not cross-react with other hnRNPCL1 or RALY proteins.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human hnRNP C1/C2 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2) has multiple biological functions including transcriptional regulation, DNA repair, and RNA processing pathways. hnRNP C1/C2 acts as a ‘molecular ruler’ in the mRNA processing pathway, committing nascent transcripts from the chromatin template to the mRNA export pathway once the nascent transcript becomes longer than 200-300 nucleotides (1). Studies indicate that without hnRNP C1/C2, the LCR-associated remodeling complex (LARC) does not associate with its target DNA sequence (2,3). LARC regulates the transcription of β-globin genes during erythropoiesis (2,3). hnRNP C1/C2, as well as other hnRNP proteins, interact with DNA damage response (DDR) proteins (4). hnRNP proteins regulate double stranded break (DSB) repair by promoting either homologous recombination (HR) or non-homologous end joining (NHEJ) (4). hnRNP C1/C2 down-regulates the expression of miR-21, which leads to the increased expression of programmed cell death 4 (PDCD4) protein in glioblastoma multiforme (GBM) (5). Research studies have shown that silencing of hnRNP C1/C2 renders GBM cells more susceptible to apoptosis (5).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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