Product Pathways - Metabolism
ANT2/SLC25A5 Antibody #12546
|12546S||100 µl (10 western blots)||---||In Stock||---|
|12546||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
ANT2/SLC25A5 Antibody recognizes endogenous levels of total ANT2/SLC25A5 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly158 of human ANT2/SLC25A5 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Adenine nucleotide translocase 2 (ANT2/SLC25A5) is a member of the adenine nucleotide translocase family of mitochondrial inner membrane proteins that function differently in metabolic and apoptotic pathways (1). Research studies indicate that ANT2 expression in undifferentiated, proliferating cells correlates with the rate of glycolytic metabolism and may be an indicator of carcinogenesis (2). Suppression of ANT2/SLC25A5 expression by specific RNA interference in human breast cancer cells promotes apoptosis and inhibits tumor cell growth (2), which suggests a cytoprotective role of ANT2/SLC25A5 (1,3).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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