Product Pathways - Metabolism
xCT/SLC7A11 (D2M7A) Rabbit mAb #12691
|12691S||100 µl (10 western blots)||---||In Stock||---|
|12691||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Species predicted to react based on 100% sequence homology: Monkey.
Specificity / Sensitivity
xCT/SLC7A11 (D2M7A) Rabbit mAb recognizes endogenous levels of total xCT/SLC7A11 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala224 of human xCT/SLC7A11 protein.
The x(c)(-) cysteine/glutamate antiporter consists of a light chain subunit (xCT/SLC7A11) that confers substrate specificity and a glycosylated heavy chain subunit (4F2hc/SLC3A2) located on the cell surface (1,2). The heterodimeric amino acid transport system x(c)(-) provides selective import of cysteine into cells in exchange for glutamate and regulating intracellular glutathione (GSH) levels, which is essential for cellular protection from oxidative stress (3). Research studies have shown that xCT expression increases in various tumors, including gliomas, and have implicated xCT in GSH-mediated anticancer drug resistance (4,5). Researchers have found that xCT provides neuroprotection by enhancing glutathione export from non-neuronal cells (6). Moreover, investigators identified xCT as the fusion-entry receptor for Kaposi's sarcoma-associated herpesvirus (7).
- Sato, H. et al. (2000) Antioxid Redox Signal 2, 665-71.
- Sato, H. et al. (1999) J Biol Chem 274, 11455-8.
- Lo, M. et al. (2008) J Cell Physiol 215, 593-602.
- Huang, Y. et al. (2005) Cancer Res 65, 7446-54.
- Liu, R. et al. (2007) Mol Pharmacol 72, 1637-46.
- Shih, A.Y. et al. (2006) J Neurosci 26, 10514-23.
- Kaleeba, J.A. and Berger, E.A. (2006) Science 311, 1921-4.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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