Product Pathways - Transcription Factors
MEIS1/2 Antibody #12744
|12744S||100 µl (10 western blots)||---||In Stock||---|
|12744||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human||Transfected Only||50, 70||Rabbit|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Species predicted to react based on 100% sequence homology: Mouse.
Specificity / Sensitivity
MEIS1/2 Antibody recognizes transfected levels of total MEIS1 and MEIS2 proteins.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MEIS1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Hox, Pbx, and Meis are families of transcription factors that bind DNA via their homeodomains. Members from each family form heterodimers to give rise to complexes with unique DNA binding specificities. Homeodomain containing proteins are frequently involved in normal developmental processes, but can also be associated with tumorigenic states (1). MEIS proteins belong to the TALE (Three Amino Acid Loop Extension) homeobox containing transcription factor family. MEIS1 has been associated with leukemogenesis and neuroblastoma (2,3) while MEIS2 is known to play an important role in the transcriptional program that is induced in normal pancreatic development (4) and cardiogenesis (5).
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