Product Pathways - Metabolism
PiT1/SLC20A1 (D1Z4X) Rabbit mAb #12765
|12765S||100 µl (10 western blots)||---||In Stock||---|
|12765||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Specificity / Sensitivity
PiT1/SLC20A1(D1Z4X) Rabbit mAb recognizes endogenous levels of total PiT1 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly290 of human PiT1 protein.
Western blot analysis of extracts from various cell lines using PiT1/SLC20A1 (D1Z4X) Rabbit mAb.
Phosphate transporter 1 (PiT1/SLC20A1) is a sodium dependent phosphate (Pi) transporter that imports Pi into cells. PiT1 was initially identified as a receptor for retroviruses (1,2). It is widely expressed in various tissues where it plays a critical role in maintaining cellular Pi homeostasis (3,4). Phosphate transporter 1 is important in cell proliferation and tumor cell growth independent of PiT1 phosphate transport function (5). Researchers have found that PiT1 is involved in TNF-α induced apoptosis (6). Moreover, phosphate uptake via PiT1 is crucial for vascular calcification (7) and overexpression of PiT1 leads to soft tissue calcification in Werner syndrome patients (8). Additional research indicates that increased PiT1 expression is seen in calcific aortic valve disease (CAVD) tissues, and that PiT1 enhances apoptosis and mineralization by modifying Akt1 levels (9).
- O'Hara, B. et al. (1990) Cell Growth Differ 1, 119-27.
- Miller, D.G. et al. (1994) Proc Natl Acad Sci U S A 91, 78-82.
- Kavanaugh, M.P. et al. (1994) Proc Natl Acad Sci U S A 91, 7071-5.
- Uckert, W. et al. (1998) Hum Gene Ther 9, 2619-27.
- Beck, L. et al. (2009) J Biol Chem 284, 31363-74.
- Salaün, C. et al. (2010) J Biol Chem 285, 34408-18.
- Li, X. et al. (2006) Circ Res 98, 905-12.
- Honjo, S. et al. (2008) Rejuvenation Res 11, 809-19.
- El Husseini, D. et al. (2013) PLoS One 8, e53393.
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For Research Use Only. Not For Use In Diagnostic Procedures.
XP® is a trademark of Cell Signaling Technology, Inc.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.