Product Pathways - Cytoskeletal Signaling
AFAP1L2/XB130 (D4A5) Rabbit mAb #12796
|12796S||100 µl (10 western blots)||---||In Stock||---|
|12796||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Monkey||Endogenous||130||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Specificity / Sensitivity
AFAP1L2/XB130 (D4A5) Rabbit mAb recognizes endogenous levels of total AFAP1L2/XB130 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val391 of human AFAP1L2/XB130 protein.
Western Blot analysis of extracts from various cell types using AFAP1L2/XB130 (D4A5) Rabbit mAb.
The actin-filament associated protein (AFAP) family consists of AFAP1, AFAP1L1, and AFAP1L2/XB130, a group of structurally similar proteins that play distinct roles in the regulation of cytoskeletal dynamics and signal transduction. Actin filament-associated protein 1-like 2 (AFAP1L2, XB130) is an adaptor protein that regulates signaling downstream of multiple kinases, including Src, Akt, and the thyroid specific kinase RET/PTC (1-3). Through these pathways, AFAP1L2/XB130 mediates transcriptional regulation, cell proliferation, motility, and microRNA expression (4,5). Research has shown that AFAP1L2/XB130 is involved in the proliferation and survival of thyroid tumor cells (6), and may have value in gastric cancer prognosis (7).
- Xu, J. et al. (2007) J Biol Chem 282, 16401-12.
- Shiozaki, A. et al. (2012) PLoS One 7, e43646.
- Lodyga, M. et al. (2009) Oncogene 28, 937-49.
- Lodyga, M. et al. (2010) J Cell Sci 123, 4156-69.
- Takeshita, H. et al. (2013) PLoS One 8, e59057.
- Shiozaki, A. et al. (2011) Am J Pathol 178, 391-401.
- Shi, M. et al. (2012) PLoS One 7, e41660.
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For Research Use Only. Not For Use In Diagnostic Procedures.
XP® is a trademark of Cell Signaling Technology, Inc.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.