Product Pathways - Transcription Factors
BACH2 Antibody #12809
|12809S||100 µl (10 western blots)||---||In Stock||---|
|12809||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
BACH2 Antibody recognizes endogenous levels of total BACH2 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala304 of human BACH2 protein. Antibodies are purified by protein A and peptide affinity chromatography.
The transcription regulator BTB and CNC homolog 2 (BACH2) is a bZIP domain-containing transcriptional repressor that dimerizes with MafK and binds Maf recognition elements (MAREs) to regulate transcription (1,2). BACH2 is part of a network of transcription factors that controls the transition of activated B cells into either antibody-producing plasma cells or memory B cells (3-5). Plasma cell differentiation requires the transcription factor Blimp1 (6). BACH2 suppresses expression of Blimp1 in activated B cells, which delays plasma cell differentiation and allows time for class switch recombination and somatic hypermutation (3-5). Genome-wide association studies have linked the genetic locus containing BACH2 to several immune-related disorders including type 1 diabetes, celiac disease, Crohn’s disease, and the skin condition known as vitiligo (7-10).
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- Shaffer, A.L. et al. (2002) Immunity 17, 51-62.
- Cooper, J.D. et al. (2008) Nat Genet 40, 1399-401.
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- Franke, A. et al. (2010) Nat Genet 42, 1118-25.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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