Product Pathways - Transcription Factors
TAL1 Antibody #12831
|12831S||100 µl (10 western blots)||---||In Stock||---|
|12831||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Species predicted to react based on 100% sequence homology: Monkey.
Specificity / Sensitivity
TAL1 Antibody recognizes transfected levels of total TAL1 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human TAL1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
The basic helix-loop-helix (bHLH) family of transcription factors play roles in a variety of developmental and adult biological settings (1). The basic (b) domain of bHLH transcription factors allows association with DNA, while the HLH domain facilitates the mono- and heterodimeric interactions required for efficient DNA binding (1). TAL1, also known as SCL, is a bHLH transcription factor that plays an essential role in the generation of embryonic hematopoietic stem cells (2), and is required for maturation of erythroid and megakaryocytic lineages in the adult (3). TAL1 interacts with Lim-domain containing proteins LMO2 and Ldb1, and has been found in complexes with these proteins as well as the hematopoietic transcription factor GATA-1 (4). Both TAL1 and LMO2 have been associated with T-cell acute lymphoblastic leukemia (T-ALL) (5,6). TAL1 activity is essential for both hematopoiesis and neurogenesis (7).
- Massari, M.E. and Murre, C. (2000) Mol Cell Biol 20, 429-40.
- Gering, M. et al. (1998) EMBO J 17, 4029-45.
- Hall, M.A. et al. (2003) Proc Natl Acad Sci U S A 100, 992-7.
- Wadman, I.A. et al. (1997) EMBO J 16, 3145-57.
- Lécuyer, E. and Hoang, T. (2004) Exp Hematol 32, 11-24.
- Rabbitts, T.H. (1998) Genes Dev 12, 2651-7.
- Bradley, C.K. et al. (2006) Eur J Neurosci 23, 1677-89.
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