Product Pathways - Protein Stability
PSMD10/Gankyrin Antibody #12985
|12985S||100 µl (10 western blots)||---||In Stock||---|
|12985||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||25||Rabbit|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Species predicted to react based on 100% sequence homology: Dog, Pig.
Specificity / Sensitivity
PSMD10/Gankyrin Antibody recognizes endogenous levels of total PSMD10/Gankyrin protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human PSMD10/Gankyrin protein. Antibodies are purified by protein A and peptide affinity chromatography.
Western blot analysis of extracts from various cell lines using PSMD10/Gankyrin Antibody.
PSMD10/Gankyrin is an ankyrin-repeat chaperone protein that is involved in the assembly of the 19S regulatory particle of the proteasome (1). Reasearch studies have demonstrated that PSMD10 is oncogenic and is overexpressed in hepatocullar carcinomas (2). Investigators believe the oncogenicity of PSMD10 may be linked to its ability to bind and regulate the stability and activity of pRB, CDK4, MDM2, and RelA (2-5).
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For Research Use Only. Not For Use In Diagnostic Procedures.