Product Pathways - Lineage Markers
DAZL (D2A4) Rabbit mAb (IHC Specific) #13057
|13057S||100 µl (10 western blots)||---||In Stock||---|
|13057||carrier free and custom formulation / quantity||email request|
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|IHC-P||1:100||Human, Mouse||Endogenous||38||Rabbit IgG|
Species cross-reactivity is determined by the application specified.
Applications Key: IHC-P=Immunohistochemistry (Paraffin)
Species predicted to react based on 100% sequence homology: Rat.
Specificity / Sensitivity
DAZL (D2A4) (IHC Specific) Rabbit mAb recognizes endogenous levels of total DAZL protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human protein.
Immunohistochemical analysis of paraffin-embedded mouse testes (left) and mouse kidney (right) using DAZL (D2A4) Rabbit mAb (IHC Specific). As expected, kidney is DAZL negative.
The human DAZ (Deleted in Azoospermia) gene family contains at least three members that encode RNA-binding proteins with a common RNA-recognition motif (1). An autosomal homolog of DAZ, DAZL (DAZ-like), is specifically expressed in germ cells and is essential for the specification of the germ cell lineage during embryogenesis and during gametogenesis in adults of both sexes (2,3). DAZL may function by directly recruiting poly(A)-binding proteins (PABPs) in order to activate silent mRNAs during germ cell development (2). Deletions encompassing the Y chromosomal DAZ genes are the most common molecularly defined cause of infertility in humans (4,5).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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