Product Pathways - Apoptosis
PEA-15 (D1G6A) Rabbit mAb #13091
|13091S||100 µl (10 western blots)||---||In Stock||---|
|13091||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse, Rat||Endogenous||15||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Specificity / Sensitivity
PEA-15 (D1G6A) Rabbit mAb recognizes endogenous levels of total PEA-15 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu60 of human PEA-15 protein.
Western blot analysis of extracts from various cell lines using PEA-15 (D1G6A) Rabbit mAb.
PEA-15 is a 15 kDa phosphoprotein expressed abundantly in astrocytes and fibroblasts as well as in tissues, including the lung and eye (1). The protein has been shown to coordinate cell growth, death, and glucose utilization (2-4). The amino-terminal DED domain of PEA-15 mediates its binding to FADD or Erk and further regulates the Erk and apoptosis signaling pathways. PEA-15 can be phosphorylated at two serine residues, Ser104 and Ser116, located within the carboxy terminus. Phosphorylation at these sites regulates binding to Erk and FADD (2,3).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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