Product Pathways - Lineage Markers
Brachyury (D5Y9I) Rabbit mAb #13165
|13165S||100 µl (10 western blots)||---||In Stock||---|
|13165||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human||Transfected Only||56||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
Brachyury (D5Y9I) Rabbit mAb recognizes transfected levels of total brachyury protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro233 of human brachyury protein.
T protein is a transcription factor that is vital for the formation of posterior mesoderm and axial development during vertebrate embryogenesis (1). The mouse homolog, brachyury, is necessary for mesodermal morphogenetic cell movements during gastrulation. Brachyury mutant mice die in utero and display deficient mesoderm formation including an abnormal notochord, missing posterior somites, and a reduced allantois (2). The corresponding brachyury gene is expressed in the notochord, as well as in chordoma tumors that occur along the spine, making it a good marker for notochord and notochord-derived tumors (3,4). A common polymorphism in the human T homolog has also been shown to be associated with development of the multifactorial neural tube defect, spina bifida (5,6).
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XP® is a trademark of Cell Signaling Technology, Inc.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.