Product Pathways - Ca / cAMP / Lipid Signaling
NIPSNAP1 (D1Y6S) Rabbit mAb #13226
|13226S||100 µl (10 western blots)||---||In Stock||---|
|13226||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||29||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Specificity / Sensitivity
NIPSNAP1 (D1Y6S) Rabbit mAb recognizes endogenous levels of total NIPSNAP1 protein. This antibody does not cross-react with NIPSNAP2 (GBAS) protein. This antibody recognizes the mature 29 kDa form of NIPSNAP1 as described in Okuda-Ashitaka, E. et al. (2012).
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg211 of human NIPSNAP1 protein.
Western blot analysis of extracts from various cell lines using NIPSNAP1 (D1Y6S) Rabbit mAb.
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1) is a member of a highly conserved family of proteins whose functions include the regulation of channel activity, mitochondrial function and cognitive function.
Interaction of NIPSNAP1 with the putative oncogene Ca2+-selective transient receptor potential vanilloid channel 6 (TRPV6) inhibits channel function at the cell membrane (1,2). In prostate cancer cells, alterations in chromatin structure that result in corresponding NIPSNAP1 gene inactivation have been implicated in the malignant phenotype (3).
In mouse brain, NIPSNAP has been shown to interact with mitochondrial amyloid precursor protein (APP), which may facilitate the effect of APP on mitochondrial function. (4). NIPSNAP1 expression is also altered in the brains of phenylketonuria (PKU) mice, implying a role for NIPSNAP1 in PKU-related cognitive impairment (5). NIPSNAP1 has also been implicated in pain transmission through its interaction with the neuropeptide nocistatin (NST) in mouse spinal cord (6).
- Schoeber, J.P. et al. (2008) Pflugers Arch 457, 91-101.
- Lehen'kyi, V. et al. (2012) J Physiol 590, 1369-76.
- Malhotra, A. et al. (2013) Cancer Biol Ther 14, 840-52.
- Tummala, H. et al. (2010) Eur J Neurosci 31, 1926-34.
- Surendran, S. et al. (2005) Neurochem Int 46, 595-9.
- Okuda-Ashitaka, E. et al. (2012) J Biol Chem 287, 10403-13.
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