Product Pathways - Adhesion
Basigin/EMMPRIN (E1S1V) Rabbit mAb #13287
|13287S||100 µl (10 western blots)||---||In Stock||---|
|13287||carrier free and custom formulation / quantity||email request|
Already purchased this product? Write a Review.
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IHC-P=Immunohistochemistry (Paraffin)
Specificity / Sensitivity
Basigin/EMMPRIN (E1S1V) Rabbit mAb recognizes endogenous levels of total EMMPRIN protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala254 of human EMMPRIN protein.
Western blot analysis of extracts from various cell lines using Basigin/EMMPRIN (E1S1V) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using Basigin/EMMPRIN (E1S1V) Rabbit mAb.
Western blot analysis of extracts from Ramos cells, untreated (-) or PNGase F-treated (+), using Basigin/EMMPRIN (E1S1V) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).
Basigin (EMMPRIN, CD147) is a type I integral membrane receptor protein belonging to the immunoglobulin superfamily (1). Basigin is a glycosylated protein with four known isoforms, of which isoform 2 is the most abundantly expressed (2). Multiple functions have been ascribed to Basigin; foremost among these is stimulating the secretion of extracellular matrix metalloproteinases by adjacent fibroblasts, a function which has been implicated in promoting tumor progression (2-4). Research studies have shown that Basigin is overexpressed by many tumor cells, and its expression level may correlate with tumor malignancy (5,6). A recent study identified the BASIGIN gene as a regulatory target of Slug, suggesting a role for Basigin in the process of epithelial-mesenchymal transition (7). Basigin has also been identified as a marker for a subset of highly suppressive regulatory T cells (8), and as an obligate receptor for the malarial parasite Plasmodium falciparum on human erythrocytes (9).
- Biswas, C. et al. (1995) Cancer Res 55, 434-9.
- Liao, C.G. et al. (2011) Mol Cell Biol 31, 2591-604.
- Sweeny, L. et al. (2012) Exp Cell Res 318, 1788-98.
- Lescaille, G. et al. (2012) BMC Cancer 12, 115.
- Piao, S. et al. (2012) J Cancer Res Clin Oncol 138, 627-35.
- Bi, X.C. et al. (2011) Clin Invest Med 34, E358.
- Wu, J. et al. (2011) Oncogene 30, 4410-27.
- Solstad, T. et al. (2011) Blood 118, 5141-51.
- Crosnier, C. et al. (2011) Nature 480, 534-7.
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
- 7003 20X LumiGLO® Reagent and 20X Peroxide
- 7074 Anti-rabbit IgG, HRP-linked Antibody
- 7075 Anti-biotin, HRP-linked Antibody
- 7720 Prestained Protein Marker, Broad Range (Premixed Format)
- 7727 Biotinylated Protein Ladder Detection Pack
- 7071 Phototope®-HRP Western Blot Detection System, Anti-rabbit IgG, HRP-linked Antibody
- 8112 SignalStain® Antibody Diluent
- 8114 SignalStain® Boost IHC Detection Reagent (HRP, Rabbit)
- 5425 Normal Goat Serum
- 9997 Tris Buffered Saline with Tween® 20 (TBST-10X)
- 8059 SignalStain® DAB Substrate Kit
For Research Use Only. Not For Use In Diagnostic Procedures.
Tween® is a registered trademark of ICI Americas, Inc.
SignalStain® is a trademark of Cell Signaling Technology, Inc.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.