Product Pathways - Development
FoxD3 (D20A9) Rabbit mAb #2019
|2019S||100 µl (10 western blots)||---||In Stock||---|
|2019||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human||Transfected Only||60||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
FoxD3 (D20A9) Rabbit mAb detects transfected levels of total FoxD3 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues at the C-terminus of human FoxD3.
FoxD3 is a member of the Forkhead Box family and is characterized by a winged-helix DNA-binding structure and the important role it plays in embryonic development (1). This transcriptional regulator is required for the maintenance of pluripotency in the pre-implantation and peri-implantation stages of mouse embryonic development (2) and is also required for trophoblast formation (3). FoxD3 is required for the maintenance of the mammalian neural crest; FoxD3(-/-) mouse embryos fail around the time of implantation with loss of neural crest-derived structures (4). FoxD3 also forms a regulatory network with Oct-4 and NANOG to maintain the pluripotency of ES cells (5,6).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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