Product Pathways - Development
WIF1 Antibody #2064
|W||M (H)||Transfected Only||42||Rabbit|
Reactivity Key: H=Human M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
WIF1 Antibody detects transfected levels of total WIF1 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln166 of human WIF1. Antibodies are purified by peptide affinity chromatography.
WIF1 (Wnt inhibitory factor 1) is a secreted protein that binds to Wnt proteins and inhibits their activity (1). It contains an N-terminal WIF domain and five EGF-like repeats (2). The WIF1 ortholog in Drosophila, Shifted, is required for Hedgehog stability and diffusion (3,4). It has been reported that WIF1 expression is downregulated in many types of cancers (5-8).
- Hsieh, J.C. et al. (1999) Nature 398, 431-6.
- Liepinsh, E. et al. (2006) J Mol Biol 357, 942-50.
- Gorfinkiel, N. et al. (2005) Dev Cell 8, 241-53.
- Glise, B. et al. (2005) Dev Cell 8, 255-66.
- Wissmann, C. et al. (2003) J Pathol 201, 204-12.
- Taniguchi, H. et al. (2005) Oncogene 24, 7946-52.
- Mazieres, J. et al. (2004) Cancer Res 64, 4717-20.
- Mazieres, J. et al. (2005) Cancer Lett 222, 1-10.
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For Research Use Only. Not For Use In Diagnostic Procedures.