Cell Signaling Technology

Product Pathways - Translational Control

Ribosomal Protein L26 Antibody #2065

Applications Reactivity Sensitivity MW (kDa) Source
W H M R Mk Endogenous 17 Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

Protocols

Specificity / Sensitivity

Ribosomal Protein L26 Antibody detects endogenous levels of total ribosomal protein L26.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human ribosomal protein L26. Antibodies are purified by protein A and peptide affinity chromatography.

Western Blotting

Western Blotting

Western blot analysis of extracts from various cell types using Ribosomal Protein L26 Antibody.

Background

Ribosomal protein L26 (RPL26) is a component of the 60S ribosomal subunit and is involved in translation (1,2). It was shown that RPL26 increases the translation of p53 mRNA by binding to its 5' untranslated region (UTR) after DNA damage. Studies found that overexpression of RPL26 enhances the binding of p53 mRNA to the ribosomes and increases p53 translation. Overexpression of RPL26 also induces cell-cycle arrest at G1 phase and increases radiation-stimulated apoptosis (2).

  1. Odintsova, T.I. et al. (2003) J Protein Chem 22, 249-58.
  2. Takagi, M. et al. (2005) Cell 123, 49-63.

Application References

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Companion Products

For Research Use Only. Not For Use In Diagnostic Procedures.

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